Curative Dose of Khaya grandifoliola. Stem Bark for the Treatment of Gastric Ulcers Using Wistar Rats

Figures & data

Table 1 Effects of increasing doses of Khaya grandifoliola. on stress-induced gastric lesions in the rat.

Treatment	Dose (mg/kg)	n	Mean ulcer index ± SEM (mm^2)	Percentage ulcerated surface	% Inhibition
Control	—	6	195.6 ± 23.6	16.3	—
Khaya grandifoliola extract.	5.4	6	94.8 ± 3.7	9	51.5
	6.4	6	68.9 ± 3.6	6.5	64.8
	7.4	6	41.5 ± 6.4	3.5	78.8
	8.4	6	20.9 ± 1.4	1.7	89.3
	9.4	6	5.4 ± 2	0.5	97.3
	10.4	6	3.3 ± 1	0.3	98.4
	11.4	6	0.6 ± 0.4	0.1	99.7
	12.4	6	0.0 ± 0.0	0.0	100
	13.4	6	0.0	0.0	100

Mean values ± SEM. p < 0.01 vs. control, Student's t.-test. Normal unstressed rats receiving no treatment had no ulcers.

Table 2 Effects of increasing doses of famotidine as control on stress-induced gastric lesions in the rats.

Treatment	Dose (mg/kg)	n	Mean ulcer index ± SEM (mm^2)	Percentage ulcerated surface	% Inhibition
Famotidine	0.135	6	101.5 ± 6.1	7.3	48.1
	0.185	6	78.3 ± 5.2	5.6	60
	0.235	6	48.5 ± 6.4	4.3	75.2
	0.285	6	21.0 ± 1.6	1.5	89.3
	0.335	6	9.9 ± 2.4	0.8	95
	0.385	6	1.0 ± 0.3	0.09	99.5
	0.435	6	0.4 ± 0.2	0.03	99.8
	0.485	6	0.0 ± 0.0	0.00	100

Mean values ± SEM. p < 0.01 vs. control, Student's t.-test. Normal unstressed rats receiving no treatment had no ulcers.

Table 3 Reactions of mice to increasing doses of Khaya grandifoliola. extract.

		Dose in g
Activity expressed		0.08	0.16	0.32	0.64	1.28	2.56	3	4	5	6	7	8
Locomotion	Increased
	Decreased						+	+	+	+	+	+	+
Bizarre reaction	In rounds				+	+	+	+	+	+	+	+	+
	Backwards			+	+	+	+	+	+	+	+	+	+
Sensitivity to:
Touch	Increased
	Reduced						+	+	+	+	+	+	+
Sound	Increased
	Reduced						+	+	+	+	+	+	+
Exploratory behavior	Increased
	Reduced						+	+	+	+	+	+	+
Aggressive behavior	Increased
	Reduced						+	+	+	+	+	+	+
Abnormal tail	Rigid
	Placid							+	+	+	+	+	+
Convulsions									+	+	+	+	+
Irritations in the eyes:
Conjuntivities									+	+	+	+	+
Swollen eyes									+	+	+	+	+
Production of tears									+	+	+	+	+
Size; weight loss								+	+	+	+	+	+
Shivering										+	+	+	+
Stool (Diarrhoea)							+	+	+	+	+	+	+
Respiration	Increased						+	+	+	+	+	+	+
	Reduced

+=Positive reaction.