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Research Article

Effects of L-Arginine, L-NAME, Methylene Blue, and Their Combinations on Corchorus olitorius. Aqueous Extract Antinociception in Mice

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Pages 430-439 | Accepted 30 Mar 2006, Published online: 07 Oct 2008

Figures & data

Figure 1 Effect of L-arginine (20 mg/kg) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ significantly (p < 0.05) when compared against the control [(dH2O + dH2O)-treated] group; b, differ significantly (p < 0.05) when compared against the respective (dH2O)-pretreated group.

Figure 1 Effect of L-arginine (20 mg/kg) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ significantly (p < 0.05) when compared against the control [(dH2O + dH2O)-treated] group; b, differ significantly (p < 0.05) when compared against the respective (dH2O)-pretreated group.

Figure 2 Effect of L-NAME (20 mg/kg) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ significantly (p < 0.05) when compared against the control [(dH2O + dH2O)-treated] group; b, differ significantly (p < 0.05) when compared against the respective (dH2O)-pretreated group.

Figure 2 Effect of L-NAME (20 mg/kg) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ significantly (p < 0.05) when compared against the control [(dH2O + dH2O)-treated] group; b, differ significantly (p < 0.05) when compared against the respective (dH2O)-pretreated group.

Figure 3 Effect of MB (20 mg/kg) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ significantly (p < 0.05) when compared against the the control [(dH2O + dH2O)-treated] group; b, differ significantly (p < 0.05) when compared against the respective (dH2O)-pretreated group.

Figure 3 Effect of MB (20 mg/kg) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ significantly (p < 0.05) when compared against the the control [(dH2O + dH2O)-treated] group; b, differ significantly (p < 0.05) when compared against the respective (dH2O)-pretreated group.

Figure 4 Effects of L-arginine, L-NAME, or its combination (L-arginine + L-NAME) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ signifcantly (p < 0.05) when compared against the control [(dH2O + dH2O)-treated] group; b,c,d, differ signifcantly (p < 0.05) when compared against the respective [(dH2O)-pretreated] group; e, differ signifcantly (p < 0.05) when compared against the respective [(L-arginine)-pretreated] group.

Figure 4 Effects of L-arginine, L-NAME, or its combination (L-arginine + L-NAME) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ signifcantly (p < 0.05) when compared against the control [(dH2O + dH2O)-treated] group; b,c,d, differ signifcantly (p < 0.05) when compared against the respective [(dH2O)-pretreated] group; e, differ signifcantly (p < 0.05) when compared against the respective [(L-arginine)-pretreated] group.

Figure 5 Effects of L-arginine, MB, or its combination (L-arginine + MB) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ signifcantly (p < 0.05) when compared against the control [(dH2O + dH2O)-treated] group; b,c,d, differ signifcantly (p < 0.05) when compared against the respective [(dH2O)-pretreated] group; e, differ signifcantly (p < 0.05) when compared against the respective [(L-arginine)-pretreated] group.

Figure 5 Effects of L-arginine, MB, or its combination (L-arginine + MB) on ASA and AECO antinociception assessed by abdominal constriction test. a, differ signifcantly (p < 0.05) when compared against the control [(dH2O + dH2O)-treated] group; b,c,d, differ signifcantly (p < 0.05) when compared against the respective [(dH2O)-pretreated] group; e, differ signifcantly (p < 0.05) when compared against the respective [(L-arginine)-pretreated] group.

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