Antihyperglycemic Activity of Aqueous Root Extract of Rubia cordifolia. in Streptozotocin-Induced Diabetic Rats

Figures & data

Table 1. Effect of R. cordifolia. aqueous root extract (RCAREt) treatment on fasting serum glucose in streptozotocin-induced diabetic rats

	Fasting serum glucose (mmol l^−1)
Groups (n = 8)	Initial (10 days after confirmation of diabetes)	Second week	Fourth week	Sixth week	Eighth week
Normal control	3.36 ± 0.01	3.38 ± 0.01	3.43 ± 0.01	3.55 ± 0.01	3.64 ± 0.01
Diabetic untreated	16.54 ± 0.25	20.02 ± 0.26	24.86 ± 0.28	28.18 ± 0.31	28.68 ± 0.29
Diabetic treated	17.21 ± 0.21	15.29 ± 0.25	12.52 ± 0.26	10.53 ± 0.28	5.03 ± 0.33

Values are given as mean ± SE, groups of eight animals each. Diabetic untreated group was compared with corresponding normal control groups. Diabetic treated groups were compared with corresponding diabetic untreated groups.

*p < 0.001.

Table 2. Effect of R. cordifolia. aqueous root extract (RCAREt) treatment on hematological parameters

Parameters	Normal control (n = 8)	Diabetic untreated (n = 8)	Diabetic treated (n = 8)
Hemoglobin (mmol l^−1)	2.18 ± 0.04	1.73 ± 0.07	2.17 ± 0.04
Red blood cells (millions/mm^3)	4.89 ± 0.11	4.96 ± 0.15	4.98 ± 0.02
Packed cell volume (%)	46.75 ± 2.13	35.00 ± 0.94	45.75 ± 1.57
Mean cell volume (µm^3)	96.24 ± 5.33	71.27 ± 3.34	93.35 ± 5.29
MCH (pg)	2.89 ± 0.08	2.24 ± 0.04	2.85 ± 0.11
MCHC (g%)	30.60 ± 1.4	32.10 ± 2.25	30.92 ± 1.13

Values are mean ± eight individual animals.

*p < 0.001; †p < 0.01.