Anticestodal Efficacy of Lasia spinosa. Extract Against Experimental Hymenolepis diminuta. Infections in Rats

Figures & data

Table 1.. Anticestodal efficacy of L. spinosa. extract against immature H. diminuta. infections in rats as monitored by eggs per gram of feces (EPG) count and worm recovery rate.

	EPG (mean±SEM)
Treatment groups (dose × mg/kg × day)	Days 18–20 (A)	Days 26–28 (B)	% Difference in EPG between A & B	No. of wormsrecovered/rat (mean±SEM)	% Worm recovery rate
Control Plant extract	17,166.7 ± 401.9	16,611.1 ± 309.9	3.2	3.8 ± 0.2	96.0
1 × 200 × 5	13,311.1 ± 177.8	4866.7 ± 492.9^a.	63.4	2.3 ± 0.2	58.5
2 × 200 × 5	11,222.2 ± 297.5	3822.2 ± 173.3^a.	65.9	1.8 ± 0.3	50.0
1 × 400 × 5	11,733.3 ± 296.1	3911.1 ± 360.1^a.	66.7	1.3 ± 0.2	33.5
2 × 400 × 5	8622.2 ± 176.6	2588.9 ± 110.8^a.	70.0	1.2 ± 0.4	33.5
1 × 800 × 5	8388.9 ± 215.7	2600.0 ± 127.7^a.	69.0	1.2 ± 0.2	33.5
2 × 800 × 5	5177.8 ± 131.8	1377.8 ± 116.3^a.	70.4	1.0 ± 0.3	25.0
1 × 1600 × 5	5844.5 ± 210.6	1533.3 ± 91.1^a.	73.8	0.8 ± 0.3	16.7
2 × 1600 × 5	2088.9 ± 58.2	800.0 ± 64.0^a.	80.8	0.7 ± 0.3	16.7
Praziquantel
1 × 5 × 5	3844.6 ± 76.3	644.5 ± 88.9^a.	83.2	0.7 ± 0.2	16.7
2 × 5 × 5	1822.2 ± 85.4	200.0 ± 100.4^a.	89.0	0.3 ± 0.2	8.5
1 × 10 × 5	1622.2 ± 47.7	155.6 ± 56.2^a.	90.1	0.3 ± 0.3	8.5
2 × 10 × 5	800.0 ± 64.4	0.0 ± 0.0	100.0	0.0 ± 0.0	0.0

^a.p < 0.001 significantly different from mean EPG (A) on days 18–20.

Table 2.. Anticestodal efficacy of L. spinosa. extract against mature H. diminuta. infections in rats as monitored by eggs per gram of feces (EPG) count and worm recovery rate

	EPG (mean ± SEM)			% Difference in EPG
Treatment groups (dose × mg/kg × day)	Days 18–20 (A)	Days 26–28 (B)	Days 36–38 (C)	A & B	A & C	No. of worms recovered/rat (mean ± SEM)	% Worm recovery rate
Control Plant extract	16,955.6 ± 669.4	16,911.1 ± 345.8	16,800.0 ± 336.4	0.3	0.9	3.7 ± 0.2	91.8
1 × 200 × 5	15,933.3 ± 1699.2	11,777.8 ± 954.9	4777.8 ± 150.7^b.	26.1	70.0	2.3 ± 0.3	58.5
2 × 200 × 5	17,388.9 ± 669.4	10,711.1 ± 498.5	4044.5 ± 2932.0^a.	38.4	76.7	1.3 ± 0.3	33.5
1 × 400 × 5	15,444.5 ± 631.7	9644.5 ± 859.1	3688.9 ± 163.9^a.	37.5	76.1	1.7 ± 0.3	41.8
2 × 400 × 5	17,000.0 ± 178.9	7733.3 ± 232.2	2755.6 ± 150.7^a.	54.5	83.8	1.0 ± 0.4	25.0
1 × 800 × 5	16,977.8 ± 791.7	7600.0 ± 205.8	2666.7 ± 157.8^a.	55.2	84.3	1.0 ± 0.3	25.0
2 × 800 × 5	17,466.7 ± 376.7	4622.2 ± 214.1	1200.0 ± 153.0^a.	73.5	93.1	0.7 ± 0.4	16.7
1 × 1600 × 5	17,311.1 ± 442.4	5177.8 ± 237.1	1711.1 ± 156.5^a.	70.1	90.1	0.8 ± 0.3	25.0
2 × 1600 × 5	16,888.9 ± 425.7	3222.2 ± 385.5	866.7 ± 110.2^a.	80.9	94.9	0.5 ± 0.2	8.5
Praziquantel
1 × 5 × 5	16,333.3 ± 823.7	3088.9 ± 312.5	800.0 ± 112.9^a.	81.1	95.1	0.7 ± 0.2	16.7
2 × 5 × 5	16,822.2 ± 190.6	600.0 ± 92.7	222.2 ± 58.8^a.	96.4	98.7	0.3 ± 8.5	8.5
1 × 10 × 5	16,200.0 ± 795.5	600.0 ± 59.6	00.0 ± 00.0	96.3	100.0	0.0 ± 0.0	0.0
2 × 10 × 5	16,977.8 ± 187.5	200.0 ± 100.4	00.0 ± 00.0	98.8	100.0	0.0 ± 0.0	0.0

^a.p < 0.01 significantly different from mean EPG (A) on days 18–20.

^b.p < 0.001 significantly different from mean EPG (A) on days 18–20.