Figures & data
Figure 1 The chemical structure of baicalein and baicalin from the roots of Scutellaria baicalensis G..
Figure 2 Effect of baicalin on immobility time in the tail suspension test in mice. In baicalin groups, mice were treated with baicalin (p.o.) once a day for 7 days. The test was performed 1 h after the last administration of baicalin. In the positive control, fluoxetine (FLU) was also given once daily for 7 days (20 mg/kg, p.o.). Data are expressed as means ± SEM. **p < 0.01, ***p < 0.001 vs. control.
Figure 3 Effect of baicalin on immobility time in the forced swimming test in mice. In baicalin groups, mice were treated baicalin (p.o.) once a day for 7 days. The test was performed 1 h after the last administration of baicalin. In the positive control, fluoxetine (FLU) was also given once daily for 7 days (20 mg/kg, p.o.). Data are expressed as means ± SEM. **p < 0.01, ***p < 0.001 vs. control.
Figure 4 Effect of baicalin on immobility time in the forced swimming test in rats. In baicalin groups, mice were treated with baicalin (p.o.) once a day for 7 days. The test was performed 1 h after the last administration of baicalin. In the positive control, fluoxetine (FLU) was also given once daily for 7 days (20 mg/kg, p.o.). Data are expressed as means ± S.E.M. **p < 0.01, ***p < 0.001 vs. control.
Table 1.. Effects of 7-day treatments with baicalin and fluoxetine (FLU) on the open field parameters recorded for 2 min in mice.
Figure 5 Sucrose consumption in stressed animals treated daily with baicalin and fluoxetine (FLU). The values are means (n = 10). Statistically significant differences indicated by ###p < 0.001 for stressed animals vs. control; **p < 0.01 and ***p < 0.001 for drug-treated stressed groups are relative to vehicle-treated stressed animals (VEH) at the indicated time points.
Figure 6 Effects of baicalin and fluoxetine (FLU) on MAO activity in rat whole brain (mean ± SEM), ###p < 0.001 when compared with control groups; *p < 0.05 and **p < 0.01 for baicalin and FLU-treated stressed groups when compared with stressed-vehicle groups.
