Screening of Five Brazilian Plants for Anti-inflammatory and Antimicrobial Activities

Figures & data

Figure 1 Effect of the ethanol extracts of Cayaponia podantha. (Cp), Helicteres gardneriana. (Hg), Melochia arenosa. (Ma), Nectandra falcifolia. (Nf), and Paullinia elegans. (Pe), administered by oral route (gavage) in the dose of 500 mg/kg of body weight, and of indomethacin (Indo), in the dose of 5 mg/kg, on the volume of exudate obtained in rats after carrageenan injection into the pleural cavity. *p < 0.05 compared with control groups (C) and **p < 0.05 compared with the indomethacin group (Student's t.-test).

Table 1.. Effect of the ethanol extracts of Cayaponia podantha. (Cp), Helicteres gardneriana. (Hg), Melochia arenosa. (Ma), Nectandra falcifolia. (Nf), and Paullinia elegans. (Pe), administered by oral route (gavage), in the dose of 500 mg/kg of body weight, and of indomethacin, in the dose of 5 mg/kg, on the total and differential leukocytes counts.

Animal groups	n	Total leukocytes	Mononuclear leukocytes	Polymorphonuclear leukocytes
Control	16	61,040 ± 3918	13,340 ± 1352	47,700 ± 3456
Indomethacin	8	64,630 ± 6522	9700 ± 1336	54,930 ± 5439
Cp	15	55,860 ± 3980	11,190 ± 951,1	44,650 ± 4202
Hg	5	41,500 ± 3694*	12,720 ± 1649	28,780 ± 2573*
Ma	20	63,310 ± 3205	13,350 ± 1156	49,960 ± 2862
Nf	13	55,750 ± 2795	8292 ± 730,7	47,458 ± 2781
Pe	5	53,900 ± 3616	10,110 ± 1425	43,790 ± 3725

n, number of test animals; *p < 0.05 compared with control groups (Student's t.-test).

Table 2.. Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the ethanol extracts of Cayaponia podantha. (Cp), Helicteres gardneriana. (Hg), Melochia arenosa. (Ma), Nectandra falcifolia. (Nf), and Paullinia elegans. (Pe).

	MIC (MBC) µg/ml
Plants	S. aureus.	B. subtillis.	E. coli.	P. aeruginosa.
Cp	>1250	>1250	>1250	>1250
Hg	>1250	>1250	>1250	>1250
Ma	625(625)	625(1250)	>1250	>1250
Nf	1250	39(78)	>1250	>1250
Pe	>1250	>1250	>1250	>1250