Comparative Antidiabetic, Hypolipidemic, and Antioxidant Properties of Phyllanthus niruri. in Normal and Diabetic Rats

Figures & data

Table 1.. Effect of PnlE on various biochemical parameters in IDDM rats.

Parameters	Normal control	Normal PnlE-treated	IDDM control	IDDM PnlE-treated
Glucose^a.	103.73 ± 4.68	99.41 ± 5.02^NS (−4)	217.50 ± 16.94*** (+110)	147.49 ± 5.20*** (−32)
Hepatic glycogen^b.	21.31 ± 0.78	22.42 ± 0.79^NS (+5)	6.11 ± 0.37*** (−71)	12.73 ± 0.52*** (+108)
Hepatic hexokinase^c.	7.87 ± 0.24	7.82 ± 0.30^NS (−1)	4.22 ± 0.24*** (−46)	5.91 ± 0.38*** (+40)
TC^a.	109.95 ± 3.25	114.50 ± 4.06^NS (+4)	153.81 ± 4.82*** (+40)	114.12 ± 3.35*** (−26)
TG^a.	88.40 ± 4.48	93.53 ± 4.56^NS (+6)	159.34 ± 6.22*** (+80)	124.96 ± 5.77*** (−22)
LDL-C^a.	24.97 ± 3.96	22.58 ± 6.33^NS (−10)	87.35 ± 4.88*** (+250)	35.22 ± 5.01*** (−60)
VLDL-C^a.	17.67 ± 2.53	18.70 ± 2.58^NS (+6)	31.86 ± 3.51*** (+80)	24.98 ± 3.26*** (−22)
HDL-C^a.	67.30 ± 2.20	73.22 ± 6.32^NS (+9)	34.59 ± 1.20*** (−49)	53.90 ± 3.30** (+56)
AI	1.64 ± 0.02	1.64 ± 0.16^NS (0)	4.47 ± 0.54*** (+173)	2.16 ± 0.39*** (−52)
Hepatic TC^b.	5.78 ± 0.22	4.76 ± 0.47^NS (−18)	6.64 ± 0.17^NS (+15)	5.53 ± 0.10* (−17)
Hepatic TG^b.	10.93 ± 0.45	10.77 ± 0.17^NS (−1)	12.31 ± 0.14* (+13)	10.60 ± 0.31*** (−14)
TBARS^d.	0.757 ± 0.05	0.754 ± 0.03^NS (0)	0.939 ± 0.06* (+24)	0.622 ± 0.03** (−34)
SOD^c.	3.45 ± 0.14	3.45 ± 0.16^NS (0)	3.15 ± 0.10^NS (−9)	3.47 ± 0.14^NS (+10)
Catalase^e.	65.28 ± 4.47	68.47 ± 6.81^NS (+5)	33.73 ± 4.29*** (−48)	58.12 ± 2.93** (+72)

Values are mean ± SEM of eight rats. *p < 0.05, **p < 0.01, ***p < 0.001, NS (non-significant).

PnlE-treated group was compared with respective vehicle-treated group. IDDM control was compared with normal control. Values in parentheseis represent the percent change.

Units: ^a.mg/dL; ^b.mg/g; ^c.U/mg protein; ^d.mM/100 g; ^e.nM H₂O₂ decomposed/s per g tissue.

Table 2.. Effect of PnlE on various biochemical parameters in NIDDM rats.

Parameters	Normal control	Normal PnlE-treated	NIDDM control	NIDDM PnlE-treated
Glucose^a.	103.73 ± 4.68	99.41 ± 5.02^NS (−4)	200.66 ± 6.29*** (+93)	168.58 ± 11.32^NS (−16)
Hepatic glycogen^b.	21.31 ± 0.78	22.42 ± 0.79^NS (+5)	8.62 ± 0.22*** (−60)	9.74 ± 0.41^NS (+13)
Hepatic hexokinase^c.	7.87 ± 0.24	7.82 ± 0.30^NS (−1)	6.37 ± 0.14** (−19)	6.81 ± 0.18^NS (+10)
TC^a.	109.95 ± 3.25	114.50 ± 4.06^NS (+4)	150.76 ± 1.58*** (+37)	131.19 ± 2.66** (−13)
TG^a.	88.40 ± 4.48	93.53 ± 4.56^NS (+6)	156.62 ± 3.94*** (+77)	126.41 ± 6.13** (−19)
LDL-C^a.	24.97 ± 3.96	22.58 ± 6.33^NS (−10)	75.71 ± 1.99*** (+203)	54.53 ± 2.30* (−28)
VLDL-C^a.	17.67 ± 2.53	18.70 ± 2.58^NS (+6)	31.31 ± 2.23*** (+77)	25.28 ± 3.47** (−19)
HDL-C^a.	67.30 ± 2.20	73.22 ± 6.32^NS (+9)	36.72 ± 0.50*** (−45)	51.53 ± 1.12* (+40)
AI	1.64 ± 0.02	1.64 ± 0.16^NS (0)	3.34 ± 0.25*** (+104)	2.62 ± 0.15** (−22)
Hepatic TC^b.	5.78 ± 0.22	4.76 ± 0.47^NS (−18)	6.57 ± 0.10^NS (+14)	5.22 ± 0.16** (−21)
Hepatic TG^b.	10.93 ± 0.45	10.77 ± 0.17^NS (−1)	13.13 ± 0.18*** (+20)	11.87 ± 0.12* (−10)
TBARS^d.	0.757 ± 0.05	0.754 ± 0.03^NS (0)	0.939 ± 0.06* (−24)	0.699 ± 0.05* (−26)
SOD^c.	3.45 ± 0.14	3.45 ± 0.16^NS (0)	3.23 ± 0.10^NS (−6)	3.48 ± 0.27^NS (+8)
Catalase^e.	65.28 ± 4.47	68.47 ± 6.81^NS (+5)	35.52 ± 2.75*** (−45)	56.11 ± 3.77* (+58)

Values are mean ± SEM of eight rats. *p < 0.05, **p < 0.01, ***p < 0.001, NS (non-significant).

PnlE-treated group was compared with respective vehicle-treated group. NIDDM control was compared with normal control. Values in parentheseis represent the percent change.

Units: ^a.mg/dL; ^b.mg/g; ^c.U/mg protein; ^d.mM/100 g; ^e.nM H₂O₂ decomposed/s per g tissue.

Figure 1 Effect of PnlE on oral glucose tolerance test.