Bioactivity Investigation of Lauraceae Trees Grown in Taiwan

Figures & data

Table 1.. Lauraceae plants collected in this study and reported bioactivity.

Species	Activity	Reference
Cinnamomum. Bl.
Cinnamomum kanehirai. Hay.	–	–
Cinnamomum camphora. (L.) Ness et Eberm.	Anti-inflammatory, Antioxidant	Lee et al., 2006
Cinnamomum philippinense. (Merr.) C. E. Chang	Thromboxane A2 receptor antagonist	Su et al., 1999
Cinnamomum osmophloeum. Kanehira	Antioxidant, Antibacterial	Chang et al., 2001a
	Anti-mite	Chen et al., 2002
	Antitumor (Jurkat and U937 cells)	Fang et al., 2004
	Antifungal	Wang et al., 2005
	Anti-inflammatory	Chao et al., 2005
Cinnamomum insularimontanum. Hay.	Antiviral	Lin et al., 2003
Cinnamomum subavenium. Miq.	–	–
Cinnamomum zeylanicum. Bl.	Antinociceptive	Atta & Alkofahi, 1998
	Antioxidant	Jayaprakasha et al., 2003
Cinnamomum iners. Reinw. Ex Bl.	–	–
Litsea. Lamk.
Litsea acuminata. (Bl.) Kurata	–	–
Litsea rotundifolia. var. oblongifolia. (Nees)	Antiplatelet aggregation, vasorelaxing	Yan et al., 2000
Litsea kostermansii. Chang	–	–
Litsea akoensis. Hay.	Antitumor (P-388, KB16, A549, and HT-29)	Chen et al., 1998
		Choi & Hwang, 2004
Litsea cubeba. (Lour.) Persoon	Anti-inflammatory, antioxidant	Hwang et al., 2005
Neolitsea. Merr.
Neolitsea parvigemma. (Hay.) Kanehira et Sasaki	Anti-inflammatory	Chen et al., 2005
Neolitsea sericea. var. aurata. (Hay.) Hatusima	Anti-mite	Furuno et al., 1994
Neolitsea variabillima. (Hay.) Kaneh. et Sasaki	–	–
Neolitsea konishii. (Hay.) Kanehira et Sasaki	Anti-inflammatory	Yu, 1994
Nothaphoebe. Bl.
Nothaphoebe konishii. (Hay.) Hay.	–	–
Machilus. Nees
Machilus zuihoensis. Hayata	Antitumor (HONE-1 and NUGC-3 cells)	Hou et al., 2003
	Antioxidant	Cheng et al., 2005
Machilus thunbergii. Sieb. Et Zucc.	Anti-inflammatory	Kim & Ryu, 2003
Machilus kusanoi. Hay
Lindera. Thunb
Lindera communis. Hemsl.	Antitumor (P-388, KB16, A549, and HT-29)	Tsai et al., 2002
Lindera aggregate. (Sims) Kosterm.	Antioxidant	Mori et al., 2004
Lindera megaphylla. Hemsl.	Vascular alpha 1-adrenoceptor antagonist	Yu et al., 1992
	Antitumor (HuH-7 and MS-G2)	Huang et al., 1998
Beilschmiedia. Nees
Beilschmiedia erythrophloia. Hay.	–	–
Cryptocarya. R. Brown
Cryptocarya concinna. Hance	–	–
Phoebe. Nees
Phoebe formosana. (Matsum. et Hay.) Hay.	–	–

–, not found.

Table 2.. DPPH free radical scavenging activities of extracts from 27 Lauraceae tree spicees.

Species	EC50 (µg/mL)
Cinnamomum.
Cinnamomum kanehirai.	>100
Cinnamomum camphora.	>100
Cinnamomum philippinense.	10.06 ± 0.74
Cinnamomum osmophloeum.	11.84 ± 1.36
Cinnamomum insularimontanum.	27.99 ± 0.01
Cinnamomum subavenium.	6.12 ± 0.08
Cinnamomum zeylanicum.	13.95 ± 1.32
Cinnamomum iners.	23.27 ± 1.05
Litsea.
Litsea acuminata.	6.85 ± 0.13
Litsea rotundifolia. var oblongifolia.	14.04 ± 0.20
Litsea kostermansii.	12.80 ± 0.85
Litsea akoensis.	22.53 ± 4.18
Litsea cubeba.	11.39 ± 0.38
Neolitsea.
Neolitsea parvigemma.	5.73 ± 0.37
Neolitsea sericea.. var. aurata.	30.57 ± 4.66
Neolitsea variabillima.	7.41 ± 0.13
Neolitsea konishii.	31 ± 2.71
Nothaphoebe.
Nothaphoebe konishii.	18.23 ± 2.53
Machilus.
Machilus zuihoensis.	11.43 ± 1.13
Machilus thunbergii.	>100
Machilus kusanoi.	18.78 ± 0.63
Lindera.
Lindera communis.	11.88 ± 1.35
Lindera aggregate.	11.28 ± 0.22
Lindera megaphylla.	37.47 ± 0.06
Beilschmiedia.
Beilschmiedia erythrophloia.	13.51 ± 0.59
Cryptocarya.
Cryptocarya concinna.	12.7 ± 0.68
Phoebe.
Phoebe formosana.	86.5 ± 1.16
Ascorbic acid	1.5 ± 0.01
Quercetin	2.3 ± 0.01

EC₅₀; 50% DPPH free radical scavenging concentration.

Figure 1 Anti-inflammatory activity of 25 tree species extracts by using NO free radical inhibition assay. (dose = 25 µg/mL).

Table 3.. Cytotoxicity activity of 15 tree species extracts against HUVEC, HL-60, and MCF-7 cells.

	EC50 (µg/mL)
Species	HUVEC	HL-60	MCF-7
Cinnamomum.
Cinnamomum osmophloeum.	>100	>100	>100
Cinnamomum subavenium.	>100	>100	>100
Cinnamomum iners.	>100	95.08 ± 1.08	>100
Litsea.
Litsea acuminata.	>100	>100	>100
Litsea rotundifolia. var oblongifolia.	>100	>100	>100
Litsea cubeba.	>100	>100	>100
Neolitsea.
Neolitsea variabillima.	>100	>100	>100
Neolitsea konishii.	>100	>100	>100
Machilus.
Machilus zuihoensis.	>100	>100	>100
Machilus kusanoi.	>100	>100	>100
Lindera.
Lindera aggregate.	43.15 ± 1.57	>100	>100
Lindera megaphylla.	>100	>100	>100
Beilschmiedia.
Beilschmiedia erythrophloia.	>100	>100	>100
Cryptocarya.
Cryptocarya concinna.	49.36 ± 5.62	>100	>100
Phoebe.
Phoebe formosana.	>100	42.87 ± 2.24	>100

EC₅₀; inhibition 50% cell survived concentration.

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