Fungicidal Effect and Oral Acute Toxicity of Psophocarpus tetragonolobus. Root Extract

Figures & data

Figure 1 Agar plate showing inhibitory zones: (A) crude extract (100 mg/mL), (B) miconazole nitrate (30 μ g/ mL), and (C) 10% DMSO (v/v).

Table 1 Fungicidal activity (zone of inhibition and MIC^a.) of Psophocarpus tetragonolobus. root extract compared with commercial antibiotic miconazole nitrate.

	Methanol extract zone of inhibition (mm)^b.
Microorganism	Crude extract	Miconazole nitrate	MIC (mg/mL) of the extract
Candida albicans	16.00	21.00	3.13

^a.Agar dilution method, mean value n = 3.

^b.The values (average of triplicate) are diameter of zone of inhibition at 100 mg/mL crude extract and 30 μ g/mL miconazole nitrate.

Figure 2 SEM micrographs of the (A) untreated and (B) extract-treated cells of Candida albicans..

Figure 3 Growth profile for Candida albicans. in Mueller-Hinton broth with 0 (control) and 3.13 mg/mL (MIC) concentration of Psophocarpus tetragonolobus. root extract.

Table 2 Effect of acute treatment of Psophocarpus tetragonolobus. root extract on the weight of the principal organs in rats.

	Males		Females
Organs	Control	2000 mg/kg extract	Control	2000 mg/kg extract
Lung/body weight (%)	1.05 ± 0.18	1.17 ± 0.23	0.81 ± 0.12	0.82 ± 0.12
Liver/body weight (%)	7.58 ± 1.44	7.12 ± 2.35	4.45 ± 0.6	4.21 ± 0.32
Spleen/body weight (%)	0.52 ± 0.20	0.49 ± 0.15	0.33 ± 0.04	0.35 ± 0.06
Heart/body weight (%)	0.74 ± 0.18	0.68 ± 0.10	0.37 ± 0.03	0.34 ± 0.04
Kidney/body weight (%)	1.79 ± 0.19	1.93 ± 0.28	0.93 ± 0.95	0.91 ± 0.93

Values are mean ± SD; p < 0.05.