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Research Article

Anti-Inflammatory, Antinociceptive, and Sedating Effects of Lafoensia pacari. Aqueous Extract

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Pages 341-346 | Accepted 08 Oct 2007, Published online: 07 Oct 2008

Figures & data

Figure 1 Effect of the aqueous extract of Lafoensia pacari. stem bark (ExH2O; 0.25, 0.5, or 1.0 g/kg, p.o.) on the sleeping time induced by sodium pentobarbital (50 mg/kg, i.p.) in mice. The vertical bars indicate the means ± SEM, expressed in relative percentage to the control group. *p < 0.05, **p < 0.01.

Figure 1 Effect of the aqueous extract of Lafoensia pacari. stem bark (ExH2O; 0.25, 0.5, or 1.0 g/kg, p.o.) on the sleeping time induced by sodium pentobarbital (50 mg/kg, i.p.) in mice. The vertical bars indicate the means ± SEM, expressed in relative percentage to the control group. *p < 0.05, **p < 0.01.

Figure 2 Effect of the aqueous extract of Lafoensia pacari. stem bark (ExH2O; 0.25, 0.5, or 1.0 g/kg, p.o.) on the number of acetic acid–induced abdominal writhes. The vertical bars represent the means ± SEM, expressed in relative percentage to the control group. Indomethacin (10 mg/kg, p.o.) was used as positive control. *p < 0.05, **p < 0.01.

Figure 2 Effect of the aqueous extract of Lafoensia pacari. stem bark (ExH2O; 0.25, 0.5, or 1.0 g/kg, p.o.) on the number of acetic acid–induced abdominal writhes. The vertical bars represent the means ± SEM, expressed in relative percentage to the control group. Indomethacin (10 mg/kg, p.o.) was used as positive control. *p < 0.05, **p < 0.01.

Figure 3 Effect of the previous treatment with the aqueous extract of Lafoensia pacari. stem bark (ExH2O; 0.5, 1.0, or 2.0 g/kg, p.o.) in the tail flexion. Morphine was used as positive control. The points indicate the means ± SEM expressed in relative percentage to the zero time. The control group was treated with vehicle (water). *p < 0.05.

Figure 3 Effect of the previous treatment with the aqueous extract of Lafoensia pacari. stem bark (ExH2O; 0.5, 1.0, or 2.0 g/kg, p.o.) in the tail flexion. Morphine was used as positive control. The points indicate the means ± SEM expressed in relative percentage to the zero time. The control group was treated with vehicle (water). *p < 0.05.

Figure 4 Effect of previous treatment with the aqueous extract of Lafoensia pacari. stem bark (ExH2O; 0.25, 0.5, or 1.0 g/kg, p.o.) on croton oil–induced ear edema in mice. The vertical bars indicate the means ± SEM of differences in weight between right and left ear plugs. Dexamethasone (2.0 mg/kg, p.o.) was used as a positive control. *p < 0.05, **p < 0.01, and ***p < 0.001.

Figure 4 Effect of previous treatment with the aqueous extract of Lafoensia pacari. stem bark (ExH2O; 0.25, 0.5, or 1.0 g/kg, p.o.) on croton oil–induced ear edema in mice. The vertical bars indicate the means ± SEM of differences in weight between right and left ear plugs. Dexamethasone (2.0 mg/kg, p.o.) was used as a positive control. *p < 0.05, **p < 0.01, and ***p < 0.001.

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