Antihyperglycemic Profile of Trichosanthes dioica. Seeds in Experimental Models

Figures & data

Table 1 Effect of graded doses of Trichosanthes dioica. seed aqueous extract on BGLs of normoglycemic rats (mean ± SD).

		BGLs (mg/dL)
			Posttreatment time
Experimental groups	Treatment (mg/kg b.w.)	Pretreatment FBG	1.5 h	3.0 h	4.5 h	6.0 h
Control	Distilled water	73.4 ± 5.1	74.1 ± 3.2	74.0 ± 4.6	73.2 ± 3.8	72.9 ± 4.2
Treated 1	500	72.5 ± 3.2	70.0 ± 3.2	64.7 ± 4.6	59.0 ± 5.1	57.7 ± 3.8
Treated 2	750	67.0 ± 3.2	61.9 ± 5.2	55.4 ± 3.9	53.3 ± 3.2	51.4 ± 5.1
Treated 3	1000	73.7 ± 4.4	68.1 ± 3.2	60.1 ± 5.2	53.2 ± 4.9	51.3 ± 4.8
Treated 4	1250	71.1 ± 5.3	68.2 ± 4.2	62.4 ± 4.8	56.3 ± 3.7	51.8 ± 4.5

*p < 0.01 compared with control.

Table 2 Effect of graded doses of Trichosanthes dioica. seed aqueous extract on BGLs during GTT of normoglycemic rats (mean ± SD).

		BGLs (mg/dl)
			Posttreatment time
Experimental groups	Treatment (mg/kg b.w.)	Pretreatment FBG	1 h	2 h	3 h	4 h	5 h
Control	Distilled water	72.6 ± 5.7	72.8 ± 3.6	72.4 ± 5.1	110.1 ± 4.3	103.4 ± 4.2	96.8 ± 5.3
Treated 1	500	70.9 ± 4.1	69.7 ± 3.7	68.3 ± 4.8	92.4 ± 4.2	82.5 ± 4.6	74.9 ± 3.8
Treated 2	750	72.3 ± 4.5	70.9 ± 4.1	67.0 ± 3.1	90.7 ± 5.1	79.1 ± 4.5	73.8 ± 3.7
Treated 3	1000	71.1 ± 4.7	69.3 ± 4.6	65.7 ± 5.1	86.2 ± 4.9	75.9 ± 4.8	71.1 ± 4.4
Treated 4	1250	71.4 ± 4.2	70.2 ± 3.2	66.4 ± 3.9	87.3 ± 4.4	76.9 ± 4.9	72.1 ± 4.9

*p < 0.01 compared with control.

Figure 1 Effect of graded doses of Trichosanthes dioica. seed aqueous extract on BGL during GTT in subdiabetic rats. *p < 0.001 compared with control. Control: distilled water. Treated 1, 500 mg/kg; Treated 2, 750 mg/kg; Treated 3, 1000 mg/kg; Treated 4, 1250 mg/kg; tolbutamide, 250 mg/kg.

Figure 2 Effect of graded doses of Trichosanthes dioica. seed aqueous extract on BGL during GTT in mild diabetic rats. *p < 0.001 compared with control. Control, distilled water. Treated 1, 500 mg/kg; treated 2, 750 mg/kg; Treated 3, 1000 mg/kg; Treated 4, 1250 mg/kg; tolbutamide, 250 mg/kg.