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Research Article

Anti-Inflammatory Effects of Scopoletin and Underlying Mechanisms

, , , , &
Pages 854-860 | Accepted 22 Apr 2008, Published online: 20 Jan 2009

Figures & data

Figure 1. Time course of edema and PGE2 levels of mouse ears in croton oil-induced dermatitis.

Figure 1.  Time course of edema and PGE2 levels of mouse ears in croton oil-induced dermatitis.

Figure 2. Effects of scopoletin and prednisolone on croton oil-induced mouse ear edema. Values were means ± SEM of 8 mice. Statistically significant difference with respect to control was expressed as **P < 0.01.

Figure 2.  Effects of scopoletin and prednisolone on croton oil-induced mouse ear edema. Values were means ± SEM of 8 mice. Statistically significant difference with respect to control was expressed as **P < 0.01.

Figure 3. Influence of l-NN pretreatment on the anti-inflammatory effects of scopoletin in croton oil-induced dermatitis. Values were means ± SEM of 8 mice.

Figure 3.  Influence of l-NN pretreatment on the anti-inflammatory effects of scopoletin in croton oil-induced dermatitis. Values were means ± SEM of 8 mice.

Figure 4. Effects of scopoletin and prednisolone on croton oil-induced ear vascular permeability in mice. Values were means ± SEM of 8 mice. Statistically significant difference with respect to control was expressed as **P < 0.01.

Figure 4.  Effects of scopoletin and prednisolone on croton oil-induced ear vascular permeability in mice. Values were means ± SEM of 8 mice. Statistically significant difference with respect to control was expressed as **P < 0.01.

Figure 5. Effects of scopoletin and prednisolone on (A) MPO activity, (B) PGE2, and (C) TNF-α levels of mouse ears in croton oil-induced dermatitis. Values were means ± SEM of 8 mice. Statistically significant difference with respect to control was expressed as *P < 0.05, **P < 0.01.

Figure 5.  Effects of scopoletin and prednisolone on (A) MPO activity, (B) PGE2, and (C) TNF-α levels of mouse ears in croton oil-induced dermatitis. Values were means ± SEM of 8 mice. Statistically significant difference with respect to control was expressed as *P < 0.05, **P < 0.01.

Figure 6. Effects of scopoletin and indomethacin on carrageenan-induced mouse hind paw edema. Values were means ± SEM of 8 mice. Statistically significant differences with respect to the control are expressed as *P < 0.05, **P < 0.01.

Figure 6.  Effects of scopoletin and indomethacin on carrageenan-induced mouse hind paw edema. Values were means ± SEM of 8 mice. Statistically significant differences with respect to the control are expressed as *P < 0.05, **P < 0.01.

Figure 7. Effects of scopoletin and indomethacin on (A) MPO activity and (B) malondialdehyde (MDA) levels in mouse hind paws injected with carrageenan. Values were means ± SEM of 8 mice. Statistically significant differences with respect to the control were expressed as *P < 0.05, **P < 0.01.

Figure 7.  Effects of scopoletin and indomethacin on (A) MPO activity and (B) malondialdehyde (MDA) levels in mouse hind paws injected with carrageenan. Values were means ± SEM of 8 mice. Statistically significant differences with respect to the control were expressed as *P < 0.05, **P < 0.01.

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