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Research Article

Cardiovascular Effects of the n-Butanol Extract from Kalanchoe Crenata Leaves

, , , , , , & show all
Pages 846-853 | Accepted 18 Apr 2008, Published online: 20 Jan 2009

Figures & data

Figure 1. Time-dependent effects of the n-butanol extract of the leaves of Kalanchoe crenata on the mean arterial blood pressure (MABP) of anesthetized normotensive rats. n = 5, cp < 0.001 compared to initial value (0 min).

Figure 1.  Time-dependent effects of the n-butanol extract of the leaves of Kalanchoe crenata on the mean arterial blood pressure (MABP) of anesthetized normotensive rats. n = 5, cp < 0.001 compared to initial value (0 min).

Figure 2. Time-dependent effects of the n-butanol extract of the leaves of Kalanchoe crenata on the heart rate of anesthetized normotensive rats. n = 5, ap < 0.05; bp < 0.01; cp < 0.001 compared to initial value (0 min).

Figure 2.  Time-dependent effects of the n-butanol extract of the leaves of Kalanchoe crenata on the heart rate of anesthetized normotensive rats. n = 5, ap < 0.05; bp < 0.01; cp < 0.001 compared to initial value (0 min).

Figure 3. Effects of the n-butanol extract of the leaves of Kalanchoe crenata on the electrocardiogram of anesthetized rat. (A) control, (B) electrocardiogram recorded 30 seconds after extract (10 mg/kg) administration showing the progressive disappearance of P and R waves as well as the reduction of heart frequency. Abs R = absence of R wave; Abs P = absence of P wave.

Figure 3.  Effects of the n-butanol extract of the leaves of Kalanchoe crenata on the electrocardiogram of anesthetized rat. (A) control, (B) electrocardiogram recorded 30 seconds after extract (10 mg/kg) administration showing the progressive disappearance of P and R waves as well as the reduction of heart frequency. Abs R = absence of R wave; Abs P = absence of P wave.

Figure 4. Time-dependent effects of different doses of the n-butanol extract of the leaves of Kalanchoe crenata on the PR and QT intervals and on the QRS duration. n = 0.5, ap < 0.05; bp < 0.01; cp < 0.001 compared to the value obtained before.

Figure 4.  Time-dependent effects of different doses of the n-butanol extract of the leaves of Kalanchoe crenata on the PR and QT intervals and on the QRS duration. n = 0.5, ap < 0.05; bp < 0.01; cp < 0.001 compared to the value obtained before.

Figure 5. Concentration-dependent effects of Kalanchoe crenata n-butanol extract (μ g/ml) and nifedipine (nM) on the electrically induced papillary muscle contraction. n = 6, ap < 0.05, cp < 0.001 significantly different compared to control.

Figure 5.  Concentration-dependent effects of Kalanchoe crenata n-butanol extract (μ g/ml) and nifedipine (nM) on the electrically induced papillary muscle contraction. n = 6, ap < 0.05, cp < 0.001 significantly different compared to control.

Figure 6. Time-dependent effects of Kalanchoe crenata n-butanol extract (100 μ g/ml) on the amplitude (A) and the repolarization time (B) of the action potential parameters. n = 4, bp < 0.01 significantly different compared to the initial value (0 min).

Figure 6.  Time-dependent effects of Kalanchoe crenata n-butanol extract (100 μ g/ml) on the amplitude (A) and the repolarization time (B) of the action potential parameters. n = 4, bp < 0.01 significantly different compared to the initial value (0 min).

Figure 7. An example of recording showing the time-dependent effect of n-butanol extract on the guinea pig papillary muscle cell.

Figure 7.  An example of recording showing the time-dependent effect of n-butanol extract on the guinea pig papillary muscle cell.

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