Effect of an Ethanol Extract of Embelia ribes Fruits on Isoproterenol-Induced Myocardial Infarction in Albino Rats

Figures & data

Table 1.  Effect of ethanol Embelia ribes extract administration on heart rate, systolic blood pressure, serum LDH and serum CK levels.

Treatment	Heart rate (BPM)	Systolic BP (mm Hg)	Serum LDH (IU/L)	Serum CK (IU/L)
Normal healthy control	417.29 ± 1.19	115.00 ± 1.25	191.11 ± 7.40	60.74 ± 3.10
Pathogenic control	544.83 ± 5.06*	122.65 ± 1.09*	488.90 ± 18.50*	747.01 ± 20.90*
Ethanol Embelia ribes extract (200 mg/kg) treated	508.01 ± 3.12^#	120.17 ± 1.37	372.51 ± 11.90^#	363.86 ± 8.27^#
Gliclazide (25 mg/kg) treated	512.67 ± 3.18^#	122.67 ± 1.91	392.11 ± 5.81^#	396.05 ± 3.77^#

*P < 0.01, as compared with group I, ^# P < 0.01, as compared with group II.

Table 2.  Effect of ethanol Embelia ribes extract administration on myocardial TBARS, GSH, SOD and CAT levels.

Treatment	TBARS (nmole MDA/mg protein)	GSH (μmoles of phosphorous liberated/min/mg protein)	SOD (IU/mg protein)	CAT (nmoles of H2O2 consumed/min/ mg protein)
Normal healthy control	0.52 ± 0.04	99.60 ± 6.01	1.41 ± 0.03	1.93 ± 0.61
Pathogenic control	3.94 ± 0.17*	23.01 ± 1.75*	0.10 ± 0.01*	0.22 ± 0.03*
Ethanol Embelia ribes extract (200 mg/kg) treated	1.61 ± 0.02^#	43.10 ± 1.52^#	0.70 ± 0.03^#	0.74 ± 0.10^#
Gliclazide (25 mg/kg) treated	2.18 ± 0.06	36.90 ± 0.72^@	0.63 ± 0.08^#	0.36 ± 0.03

* P < 0.01, as compared with group I, ^# P < 0.01, as compared with group II.

Figure 1.  Normal healthy control group (i.e., group I) rat heart section, showing normal myocardial fibres (10 x).

Figure 2.  Pathogenic control group (i.e., group II) rat heart section, showing, (A) Marked inflammatory infiltrate with (B) edema (10 x).

Figure 3.  Ethanol Embelia ribes extract pretreatment group (i.e., group III) rat heart section, showing normal myocardial fibres (10 x).

Figure 4.  Gliclazide pretreatment group (i.e., group IV) rat heart section, showing normal myocardial fibres (10 x).