Effect of Asparagus racemosus on sexual dysfunction in hyperglycemic male rats

Figures & data

Table 1.  Effect of various treatments on body and organ weight.

Group	Weight of animal (g)		Weight of testes (g)		Weight of prostate (mg)		Blood glucose level in mg/dL
	0 days	28 days	0 days	28 days	0 days	28 days	0 days	28 days
Group I	221.5 ± 0.84	224.1 ± 0.84	0.86 ± 0.01	0.88 ± 0.01	95.1 ± 1.5	96.6 ± 1.4	105 ± 2.1	106.2 ± 1.3
Group II	220.1 ± 0.61	192.6 ± 0.82	0.84 ± 0.1	0.62 ± 0.08	96.5 ± 1.2	78.1 ± 2.1	229.1 ± 1.2	233.15 ± 2.01
Group III	220.3 ± 0.5	216.4 ± 1.1**	0.87 ± 0.01	0.83 ± 0.01**	92.1 ± 1.2	97.2 ± 1.8*	229.4 ± 1.12	112.4 ± 2.01**
Group IV	221.3 ± 0.8	198.4 ± 0.1**	0.86 ± 0.01	0.60 ± 0.02*	94.2 ± 1.6	75.2 ± 2.18*	234 ± 0.98	265 ± 3.11
Group V	220.6 ± 0.81	218.7 ± 0.94**	0.84 ± 0.01	0.95 ± 0.02**	97.1 ± 1.1	88.1 ± 1.1**	246 ± 1.2	116.63 ± 2.06**

Group I: (no treatment) served as control and was administered vehicle only.

Group II: 50 mg/kg b.w. streptozotocin i.p. once.

Group III: 50 mg/kg b.w. streptozotocin i.p. once and 200 mg/kg BW A. racemosus extract orally.

Group IV: a single dose of 100 mg/kg BW alloxan i.p.

Group V: a single dose of 100 mg/kg BW alloxan i.p. and 200 mg/kg BW aqueous extract of A. racemosus.

*P < 0.05 considered significant, **P < 0.01 considered extremely significant.

Table 2.  Effect of various treatments on sexual behavior in male rats after 28 days of treatment.

Parameters	Treated groups
	Group I	Group II	Group III	Group IV	Group V
Mount latency ML (mean time ± SE in sec)	169.9 ± 12.6	271.2 ± 11.2**	163.2 ± 8.2**	293.2 ± 8.2**	138.2 ± 2.1
Intromission latency IL (mean time ± SE in sec)	313.2 ± 10.8	412.6 ± 7.4**	276.2 ± 7.1**	416.2 ± 7.1**	266.8 ± 4.4*
Post ejaculatory latency PEL (mean time ± SE in sec)	496.7 ± 5.8	761 ± 2.3**	469.4 ± 2.1**	772 ± 2.1**	416.6 ± 9.2
Hesitation time (mean time ± SE in sec)	330 ± 8	520 ± 2**	231 ± 2**	531 ± 2**	129 ± 9*
Intromission frequency IF	6.2 ± 0.1	2.1 ± 0.4**	5.7 ± 0.3**	1.7 ± 0.3**	6.9 ± 1.0
Ejaculation frequency EF	3.1 ± 0.9	0.2 ± 0.01**	3.1 ± 0.02**	0.1 ± 0.02**	3.6 ± 0.9*
Mount frequency MF	15.6 ± 3.9	4.8 ± 2.9**	12.3 ± 1.4**	5.3 ± 1.4**	11.8 ± 3.4*
Number of bouts	0.6 ± 0.3	0.1 ± 0.02**	1. 1 ± 0.07**	0. 1 ± 0.07**	1.2 ± 0.08*
Percent ejaculating animals	68.6 ± 0.3	21.2 ± 0.5**	78.2 ± 0.5**	28.2 ± 0.5**	74 ± 1.05*
Cumulative score for attraction towards female	22 ± 2	6 ± 1.2**	49 ± 1.1**	8 ± 1.1**	79 ± 1**
Penile erection index (PEI)	21.2 ± 1.1	6.2 ± 0.6**	27.1 ± 0.4**	7.1 ± 0.4**	36.2 ± 1.1**

Group I: (no treatment) served as control and was administered vehicle only.

Group II: 50 mg/kg BW streptozotocin i.p. once.

Group III: 50 mg/kg BW streptozotocin i.p. once and 200 mg/kg BW A. racemosus extract orally.

Group IV: a single dose of 100 mg/kg BW alloxan i.p.

Group V: a single dose of 100 mg/kg BW alloxan i.p. and 200 mg/kg BW aqueous extract of A. racemosus.

*P < 0.05 considered significant, **P < 0.01 considered extremely significant.

One way anova followed by Dunnet’s test comparing all versus control.