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Research Article

Aqueous extracts of FBD, a Chinese herb formula composed of Poria cocos, Atractylodes macrocephala, and Angelica sinensis reverse scopolamine induced memory deficit in ICR mice

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Pages 396-401 | Received 22 Jan 2008, Accepted 20 Jun 2008, Published online: 01 May 2009

Figures & data

Figure 1. Effects of aqueous extracts of FBD on memory dysfunction in mice induced by scopolamine in step-through passive avoidance test. Data represent means ± SD of 10 mice per group. ##p < 0.01 compared with control group; *p < 0.05, **p < 0.01 compared with saline-treated group.

Figure 1.  Effects of aqueous extracts of FBD on memory dysfunction in mice induced by scopolamine in step-through passive avoidance test. Data represent means ± SD of 10 mice per group. ##p < 0.01 compared with control group; *p < 0.05, **p < 0.01 compared with saline-treated group.

Figure 2. Effects of aqueous extracts of FBD on memory dysfunction in mice induced by scopolamine in water maze test. Data represent means ± SD of 10 mice per group. ##p < 0.01, ###p < 0.001 compared with control group; *p < 0.05, **p < 0.01, ***p < 0.001 compared with saline-treated group.

Figure 2.  Effects of aqueous extracts of FBD on memory dysfunction in mice induced by scopolamine in water maze test. Data represent means ± SD of 10 mice per group. ##p < 0.01, ###p < 0.001 compared with control group; *p < 0.05, **p < 0.01, ***p < 0.001 compared with saline-treated group.

Figure 3. lnhibitory activities of FBD aqueous extracts on cortical and hippocampal acetylcholinesterase activity and circulating butyrylcholinesterase activity in mice treated with scopolamine in vivo. AChE, acetylcholinesterase; Data represent means ± SD of 10 mice per group. ###p <0.001 compared with control group; **p < 0.01 compared with saline-treated group.

Figure 3.  lnhibitory activities of FBD aqueous extracts on cortical and hippocampal acetylcholinesterase activity and circulating butyrylcholinesterase activity in mice treated with scopolamine in vivo. AChE, acetylcholinesterase; Data represent means ± SD of 10 mice per group. ###p <0.001 compared with control group; **p < 0.01 compared with saline-treated group.

Figure 4. lnhibitory activities of FBD aqueous extracts on circulating butyrylcholinesterase activity in mice treated with scopolamine in vivo. BChE, butyrylcholinesterase. Data represent means ± SD of 10 mice per group. ##p <0.01 compared with control group; *p < 0.05, **p < 0.01 compared with saline-treated group.

Figure 4.  lnhibitory activities of FBD aqueous extracts on circulating butyrylcholinesterase activity in mice treated with scopolamine in vivo. BChE, butyrylcholinesterase. Data represent means ± SD of 10 mice per group. ##p <0.01 compared with control group; *p < 0.05, **p < 0.01 compared with saline-treated group.

Figure 5. Inhibitory activities of FBD or F/B/D aqueous extracts on acetylcholinesterase activity in cortical and hippocampal homogenates in vitro. Inhibitory activities were expressed as percentage inhibition of AChE activity compared to the control value (100%). AChE, acetylcholinesterase; F, Fuling; B, Baizhu; D, Danggui. Data represent means ± SD in triplicate. *p < 0.05, **p < 0.01 compared with the control.

Figure 5.  Inhibitory activities of FBD or F/B/D aqueous extracts on acetylcholinesterase activity in cortical and hippocampal homogenates in vitro. Inhibitory activities were expressed as percentage inhibition of AChE activity compared to the control value (100%). AChE, acetylcholinesterase; F, Fuling; B, Baizhu; D, Danggui. Data represent means ± SD in triplicate. *p < 0.05, **p < 0.01 compared with the control.

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