Study of anti-inflammatory and antinociceptive activity of hydroalcoholic extract of Schima wallichii bark

Figures & data

Figure 1.  Effect of hydroalcoholic extract of Schima wallichii bark on carrageenan induced paw edema in rats (n = 6). *p <0.05 compared with control group. **p <0.01 compared with control group.

Figure 2.  Effect of hydroalcoholic extract of Schima wallichii bark on dextran induced paw edema in rats (n = 6). *p <0.05 compared with control group. **p <0.01 compared with control group.

Table 1.  Effect of hydroalcoholic extract of Schima wallichii bark on cotton pellet granuloma in rats.

Treatment	Weight of granuloma (mg)	% inhibition
Control (distilled water)	33.32 ± 2.54
HESW (150 mg/kg)	25.35 ± 1.81*	23.92
HESW (300 mg/kg)	23.67 ± 2.06*	28.96
Indomethacin (10 mg/kg)	20.83 ± 1.80**	37.48

Values are expressed as mean ± SEM (n = 6).

*p <0.05 compared with control group.

**p <0.01 compared with control group.

Table 2.  Effect of hydroalcoholic extract of Schima wallichii bark on acetic acid induced writhing in mice.

Groups	Onset of writhing (s)	Number of writhings(% inhibition)
Normal control	245.83 ± 8.75	37.83 ± 3.99
HESW (50 mg/kg, orally)	826.17 ± 27.28**	26.17 ± 2.44* (30.82)
HESW (100 mg/kg, orally)	497.33 ± 14.98**	18.67 ± 2.29** (50.65)
Paracetamol (50 mg/kg, orally)	508.5 ± 53.49**	13.33 ± 2.58** (64.76)

Values are expressed as mean ± SEM (n = 6).

*p <0.05 compared with control group.

**p <0.01 compared with control group.

Table 3.  Evaluation of analgesic activity of hydroalcoholic extract of Schima wallichii bark by the hot-plate method.

Groups	Latency to lick the paw (s)
	0	30	60	90	120	150
Normal control	4.00 ± 0.37	4.17 ± 0.31	4.33 ± 0.33	4.33 ± 0.21	4.50 ± 0.43	4.67 ± 0.33
Extract (50 mg/kg)	4.83 ± 0.17	6.50 ± 0.43**	9.50 ± 0.76**	7.83 ± 0.60**	5.67 ± 0.33	4.83 ± 0.48
Extract (100 mg/kg)	4.50 ± 0.43	6.83 ± 0.31**	10.83 ± 0.31**	8.17 ± 0.48**	6.33 ± 0.49*	5.33 ± 0.21
Pentazocine (10 mg/kg)	4.50 ± 0.22	8.83 ± 0.40**	13.50 ± 0.56**	8.83 ± 0.85**	7.83 ± 0.48**	5.67 ± 0.33

Values are expressed as mean ± SEM (n = 6).

*p <0.05 compared with control group.

**p <0.01 compared with control group.

Figure 3.  Effect of hydroalcoholic extract of Schima wallichii bark on yeast-provoked elevated body temperature (n = 6). *p<0.05 compared with control group. **p <0.01 compared with control group.