Hydroxysafflor yellow A reduces myocardial infarction size after coronary artery ligation in rats

Figures & data

Figure 1.  The chemical structure of HSYA.

Table 1.  Effect of HSYA on myocardial infarction size (MIS) and creatine kinase (CK-MB) activity in acute myocardial ischemic rats.

Group	Dose (mg/kg)	MIS (%)	CK-MB( U/L )
Sham	—	0	1017.5 ± 182.9
Control	—	22.5 ± 4.8^##	1447.8 ± 140.9^##
HSYA	2	20.1 ± 3.1	1284.4 ± 156.1
HSYA	4	16.5 ± 3.3*	1254.9 ± 166.1*
HSYA	8	14.5 ± 3.1**	1162.8 ± 145.3**

^##p <0.01 versus sham group; *p <0.05, **p <0.01 versus control group.

Figure 2.  Effect of HSYA on SOD activity in heart tissues of acute myocardial ischemic rats. Data are means ± SD of 8 rats, except 6 rats in sham group. ^##p <0.01 versus sham group; *p <0.05, **p <0.01 versus control group.

Figure 3.  Effect of HSYA on MDA content in heart tissues of acute myocardial ischemic rats. Data are means ± SD of 8 rats, except 6 rats in sham group. ^##p <0.01 versus sham group; **p <0.01 versus control group.

Figure 4.  Effect of HSYA on eNOS activity in heart tissues of acute myocardial ischemic rats. Data are means ± SD of 8 rats except 6 rats in sham group. ^##p <0.01 versus sham group; *p <0.05, **p <0.01 versus control group.

Figure 5.  Effect of HSYA on NO content in heart tissues of acute myocardial ischemic rats. Data are means ± SD of 8 rats, except 6 rats in sham group. ^##p <0.01 versus sham group; *p <0.05, **p <0.01 versus control group.