Evaluation of the aqueous extract of Rotula aquatica roots in acute and chronic inflammatory conditions in rats

Figures & data

Table 1.  Effect of aqueous extract of R. aquatica roots on carrageenan-induced paw edema in rats.

Treatment	Dose (mg kg^−1, p.o.)	Paw edema (cm)	Inhibition %
Control	–	2.87 ± 0.17
Ibuprofen	25	1.29 ± 0.14*	61.78
R. aquatica	50	2.10 ± 0.05*	26.82
	100	2.05 ± 0.05*	28.56
	200	1.88 ± 0.03*	34.64

Values are expressed as mean ± SEM (n = 6). *p < 0.05 compared with control group.

Table 2.  Effect of aqueous extract of R. aquatica roots on cotton pellet induced granuloma in rats.

Treatment	Dose (mg kg^−1, p.o.)	Dry Granuloma weight (mg)	Inhibition %
Control	–	41.45 ± 2.40
Prednisolone	5	18.65 ± 0.27	55.00
R. aquatica	50	34.25 ± 2.1*	17.37
	100	31.70 ± 0.2*	23.52
	200	30.40 ± 1.0*	26.65

Compounds were administered orally for 7 days. Values are expressed as mean ± SEM (n = 6). *p < 0.05 compared with control group.

Table 3.  Effect of aqueous extract of R. aquatica roots on crystal induced inflammation in rats at 24 h.

Treatment	Dose (mg kg^−1, p.o.)	Total WBC (mm^3)	Neutrophil count	Monocyte count
Control	–	18930 ± 1312.00	70.00 ± 5.04	9.66 ± 0.33
Colchicine	0.1	15500 ± 346.41*	56.33 ± 1.45*	4.66 ± 0.33*
R. aquatica	50	17000 ± 305.50	65.67 ± 1.15	5.66 ± 0.66
	100	16500 ± 680.70	53.67 ± 1.45	7.66 ± 1.85
	200	15630 ± 318.00*	56.00 ± 3.46*	3.66 ± 0.33*

Values are expressed as mean ± SEM (n = 6). *p < 0.05 compared with control group.

Table 4.  Effect of aqueous extract of R. aquatica roots on IL-6 levels in the rat pouch exudates at 24 h.

Treatment	Dose (mg kg^−1, p.o.)	Rat IL-6 levels (pg mL^−1)	Inhibition %
Control	–	525.93 ± 36.71	–
Colchicine	0.1	101.93 ± 26.30*	80.61
R. aquatica	50	332.16 ± 48.86*	36.84
	100	313.70 ± 22.19*	40.35
	200	199.93 ± 16.67*	61.98

Values are expressed as mean ± SEM (n = 6). *p < 0.05 compared with control group.