Inhibition of angiotensin converting enzyme activity by five Senecio species

Figures & data

Table 1.  Content (g) of methanol extracts and fractions of Senecio species.

Plants	Dried Plant	MeOH	CH2Cl2	n-Hexane	EtOAc
S. ambiguus subsp. ambiguus	536.7	67.1	5.0	6.7	5.6
S. gibbosus subsp. gibbosus	461	63.8	1.4	1.0	6.1
S. leucanthemifolius	974.5	147.9	3.9	10.5	9.1
S. inaequidens	300	13.4	0.4	1.6	0.6
S. vulgaris	733.2	80.4	1.4	10.5	3.0

Figure 1.  Dose-dependent inhibition of ACE by Senecio species EtOAc and n-hexane extracts. Each data point represents the mean ± SD (n = 3).

Table 2.  ACE inhibitory activity (IC50) of Senecio species (μg/mL).

Plants	n-Hexane	CH2Cl2	EtOAc
S. ambiguus subsp. ambiguus	306.9 ± 3.7	–	219. 4 ± 1.7
S. gibbosus subsp. gibbosus	–	> 330	309.4 ± 3.1
S. leucanthemifolius	–	> 330	–
S. inaequidens	> 330	–	192.1 ± 1.8
S. vulgaris	–	–	327. 8 ± 3.4

The values represents means of two different experiments under standard assay conditions described in the text ± s.d (n = 3). –: Not active. Captopril (38 nM) was used as a control positive.