Hypoglycemic activity of aqueous seed extract of Hunteria umbellata in normal and streptozotocin-induced diabetic rats

Figures & data

Table 1.  Effect of a single oral high dose of the aqueous seed extract of H. umbellata on some hematological parameters 24 h post-administration in rats.

Treatment groups	Hematological parameters
	WBC (10^3/μL)	PCV (%)	PC (10^3/μL)
Control	13.44 ± 0.52	41.34 ± 3.31	1076 ± 60.72
H. umbellata (17.5 g/kg)	14.20 ± 0.96	43.52 ± 1.19	862.6 ± 69.78*

Data are mean ± SEM values for five rats in each group. WBC, white blood cell count; PCV, packed cell volume (hematocrit); PC, platelet count; *P < 0.05 as compared to the control.

Figure 1.  Percentage change in fasting blood glucose after oral administration of single daily doses of extract to normal rats. Data are mean ± SEM values for five rats in each group.*P < 0.05, **P < 0.01, ***P < 0.001 as compared to the corresponding time point for control.

Figure 2.  Percentage change in fasting blood glucose after oral administration of single daily doses of extract in diabetic rats. Data are mean ± SEM values for five rats in each group.*P < 0.05, **P < 0.01, ***P < 0.001 as compared to the control.

Table 2.  Effect of the aqueous seed extract on liver glycogen in normal and diabetic rats.

Treatment group	Normal rats		Diabetic rats
	Liver glycogen conc. (mg/100g)	% change	Liver glycogen conc. (mg/100g)	% change
Control	85.50 ± 7.5	-	42.32 ± 3.35	-
Glibenclamide (5 mg/kg)	88.16 ± 3.9	3.11	65.88 ± 7.5^a	55.67
HU (400 mg/kg)	77.62 ± 3.53	−9.21	57.38 ± 3.86^a	35.59
HU (800 mg/kg)	67.5 ± 3.51^b	−21.05	61.25 ± 5.24^a	44.73
HU (1000 mg/kg)	66.38 ± 6.03^b	−22.36	51.76 ± 2.4	22.3

Data are mean ± SEM values for five in each group.

^aP < 0.05 as compared to the control; ^bP < 0.05 compared to glibenclamide; HU, H. umbellata.