Effects of Ginkgo leaf tablets on the pharmacokinetics of losartan and its metabolite EXP3174 in rats and its mechanism

Figures & data

Figure 1. The mean concentration-time curves in rat plasma after oral administration of losartan or both GLT and losartan. (A) losartan; (B) EXP3174.

Table 1. Pharmacokinetic parameters of losartan and EXP3174 in male Sprague–Dawley rats following oral administration of losartan alone (Group A) or both losartan and GLT (Group B).

Parameter	Losartan		EXP3174
	Group A	Group B	Group A	Group B
Tmax (h)	0.39 ± 0.08	0.51 ± 0.10*	7.98 ± 1.02	3.34 ± 0.63*
Cmax (mg L^−1)	1.22 ± 0.25	1.85 ± 0.37*	1.05 ± 0.19	0.72 ± 0.12*
t1/2 (h)	3.94 ± 0.62	4.75 ± 0.52*	4.42 ± 0.35	4.99 ± 0.51
AUC(0–t) (mg h L^−1)	6.99 ± 1.05	11.94 ± 1.79*	13.12 ± 2.52	7.28 ± 1.07*
Oral CL (L h^−1 kg^−1)	1.43 ± 0.29	0.82 ± 0.21*	0.75 ± 0.14	1.29 ± 0.25*

*p < 0.05 indicates significant differences from the control.