Antibacterial, antifungal and cytotoxic properties of some sulfonamide-derived chromones

Figures & data

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Table I.  Primary screening of the Schiff bases (1) - (5) for antibacterial activity (zone of inhibition in mm).

	Microbial species
	Gram-negative				Gram-positive
Compound No.	E.coli	P.aeruginosa	S.typhi	S.flexneri	B.subtilis	S.aureus
1	22	18	22	23	27	26
2	14	10	18	18	22	16
3	08	19	07	20	19	22
4	20	17	21	23	27	27
5	21	18	22	24	28	28
Imipenum	30	24	25	27	33	33

< 10: weak; 10–16: moderate; >16: significant.

Table II.  Minimum Inhibitory Concentration (M) of Compounds (1), (4) and (5) against Selected Bacteria.

	1	4	5
Gram-negative
S.typhi	2.2908 × 10^− 8	6.749 × 10^− 8	2.043 × 10^− 8
S. flexneri	2.2908 × 10^− 8	2.699 × 10^− 8	2.043 × 10^− 8
Gram-positive
B. subtilis	>2.2908 × 10^− 7	1.349 × 10^− 7	2.043 × 10^− 8
S.aureus	>2.2908 × 10^− 7	>2.699 × 10^− 7	2.043 × 10^− 7

Table III.  In-vitro Antifungal Activity data for Schiff's bases (1) - (5) (zone of inhibition in mm).

No	T.longifusus	C. albican	A. flavus	M. canis	F. solani	C. glaberata
1	23	25	10	26	24	16
2	24	14	26	25	23	27
3	25	27	26	26	24	27
4	22	07	28	24	22	25
5	26	13	25	26	08	28
Miconazole	32	35	34	30	30	35
Amphotericin B	30	33	35	32	28	32

< 10: weak; 10–16: moderate; >16: significant.

Table IV.  Brine shrimp bioassay data for Schiff's bases (1) - (5).

Compound	LD50 (M)
1	< 2.920 × 10^− 3
2	< 2.601 × 10^− 3
3	< 2.361 × 10^− 3
4	2.732 × 10^− 4
5	2.290 × 10^− 4