Synthesis and evaluation of novel N–H and N-substituted indole-2- and 3-carboxamide derivatives as antioxidants agents

Figures & data

Figure 1 Synthesis of compounds 1–8.

Table I.  Inhibition of SOD and LP by compounds 1–8.

Comp.	X	R1	R2	Concentration in incubation medium (M)	% Inhibition^§ of SOD	% Inhibition^§ of LP
1	–	H	Cl	10^− 3	95 ± 1.4	23 ± 5.0
				10^− 4	8.0 ± 0.7	26 ± 2.1
2	–	Cl	F	10^− 3	98 ± 1.4	48 ± 2.1
				10^− 4	25 ± 5.0	38 ± 6.0
3	H	H	Cl	10^− 3	99 ± 0.7	48 ± 3.5
				10^− 4	NA	31 ± 5.5
4	H	Cl	F	10^− 3	98 ± 3.5	81 ± 3.5
				10^− 4	NA	30 ± 7.1
5	F	H	Cl	10^− 3	100 ± 0.7	81 ± 5.0
				10^− 4	NA	33 ± 3.5
6	F	Cl	F	10^− 3	100 ± 1.4	94 ± 4.2
				10^− 4	NA	26 ± 3.5
7	H	H	Cl	10^− 3	99 ± 1.4	21 ± 1.4
				10^− 4	18 ± 0.7	5.0 ± 3.5
8	H	Cl	F	10^− 3	100 ± 0.7	36 ± 4.2
				10^− 4	5 ± 0.7	10 ± 5.6
Vit E				10^− 3	87 ± 1.4	68 ± 1.4
				10^− 4	14 ± 0.9	52 ± 2.1

^§Each value represents the mean ± S.D. of three experimental results.

Compounds were dissolved in DMSO/MeOH (5:95).

NA; not active.