Effects of nicotine and vitamin E on 6-phosphogluconate dehydrogenase activity in some rat tissues in vivo and in vitro

Figures & data

Figure 1 In vivo effects of nicotine and nicotine + vitamin E on rat muscle, heart, lungs, testicle, and liver tissue 6-phosphogluconate dehydrogenase enzyme activity (Signicifant, *nicotine versus control, ⁺nicotine + vitamin E versus control, ^ψnicotine + vitamin E versus nicotine, (Significant (*P, ⁺P, and ^ψP < 0.05; ^**P, ⁺⁺P < 0.02; ***P and ^ψψψP < 0.001, n = 8).

Table I.  In vitro effects of nicotine and nicotine + vitamin E on 6-phosphogluconate dehydrogenase activity in the various rat tissues.

	Tissues Volume (μL)	Muscle (Activity%)	Heart (Activity%)	Lungs (Activity%)	Testicle (Activity%)	Liver (Activity%)
Nicotine (5 mM)	Control	100	100	100	100	100
	20	104	96	102	102	100
	40	113	98	103	103	100
	60	116	101	109	103	101
	80	122	99	115	107	102
	100	126	102	117	108	99
Nicotine (5 mM)+ Vitamin E (10 mM)	Control	100	100	100	100	100
	20	102	100	99	104	103
	40	106	100	99	107	104
	60	112	101	100	111	110
	80	116	100	100	110	114
	100	116	100	99	110	116