Carbonic anhydrase inhibitory properties of some uracil derivatives

Figures & data

Figure 1. Tautomeric forms of Uracil: lactam-lactim.

Figure 2. Structure of tested compounds.

Table 1. hCA I and II inhibition data some compounds, by an esterase assay with 4-nitrophenylacetate as substrate.^12b

	KI (μM)*
	Compound	hCA I	hCA II
4^a		428	645
5^a	10.83	28.88
6^a	57.76	NE
7^a	49.51	NE
8^a	316.2	166.4
Orotic acid (9)	0.7325	1.682
Isoorotic acid (10)	0.4585	1.432
6-Amino 1,3-Dimethyluracil (11)	0.085	0.1715
5,6-Diamino 1,3-Dimethyluracil (12)	0.1035	0.2360
13^b	795	7.7
14^b	4003	9.9
15^b	10.2	5.5

^aFrom Ref. 17. ^bFrom Ref. 27. NE: No-effect.

* Mean from at least three determinations. Errors in the range of 1–3% of the reported value (data not shown).