Prevalence of healthcare workers fully vaccinated against hepatitis B without circulating antibodies in Italy and role of age at baseline cycle vaccination: a systematic review and meta-analysis

Figures & data

Figure 1. Flow-chart of the bibliographic research.

Table 1. Characteristics of the selected studies included in meta-analysis and systematic review.

First author	Year		Quality	Susceptible HCWs (n)	Total sample	Study period	booster dose	seroconversion	Sample age	Italian region	Population
		Quantitative study
Di Giampaolo L**	2022		high	452	1052	2015–2018	-	-	23.9 ± 3.0	Marche	students
Sartorelli P	2022		high	257	850	2018–2020	-	-	23.0 ± 2.5	Tuscany	students
Cocchio S	2021		high	103	539	2005–2019	-	-	21.6 ± 4.8	Veneto	HCWs
Mastrodomenico M	2021		high	103	342	2017–2019	-	-	26.1 ± 4.2	Abruzzo	students
Trevisan A	2021		high	3679	11,188	2004–2020	-	-	Born from 1980 to 1995	Veneto	students
Bianchi FP	2020		high	30	181	2017–2019	20	19	38.6 ± 10.7	Apulia	HCWs
Garzillo EM	2020		high	189	956	2016	-	-	46.7 ± 11.1	Campania	HCWs
Grazzini M**	2020		high	-	-	2015–2017	795	698	Born between 1980 and 1998	Tuscany	HCWs
Papadopoli R	2020		high	483	1374	2014–2018	231	213	24.8 ± 5.1	Calabria	students
Verso MG	2020		high	254	483	2015–2020	254		21.7 ± 3.7	Sicily	students
Bianchi FP	2019		high	1174	3113	2014–2017	903	821	24.0 ± 5.0	Apulia	students, residents
Coppeta L	2019		high	88	734	2018	58	52	Born after 1980	Latium	HCWs, students
Rapisarda V	2019		moderate	37	212	2017	-	-	30.2 ± 2.5	Sicily	residents
Stefanati A	2019		high	172	621	2011–2018	94	87	24.0 ± 2.7	Emilia-Romagna	students, residents
Bini C	2018		high	678	2203	2014–2015	330	293	Born from 1980 to 1996	Tuscany	HCWs, students
Dini G	2017		high	210	717	2011–2013	210	200	24.8 ± 4.6	Liguria	students
La Fauci V	2016		moderate	4	88	1998–2008	-	-	<30 – >51	Sicily	HCWs
		Qualitative study
Bechini A	2021		-*	-	-	-	-	-		-	-
Trevisan A	2017		-*	-	-	-	-	-		-	-

HCWs = healthcare workers

*quality not assessed; **short report; ***letter

Figure 2. Forest plot of the pooled prevalence of serosusceptibility to hepatitis B.

Figure 3. Forest plot of the pooled prevalence of seroconversion after booster dose.

Figure 4. Funnel plot with pseudo 95% confidence limits.