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Expert Review of Vaccines Volume 22, 2023 - Issue 1
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Special Report

From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access

Peter J. Hoteza Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA;b Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USACorrespondence[email protected]
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Rakesh Adhikaria Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Wen-Hsiang Chena Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Yi-Lin Chena Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Portia Gillespiea Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Nelufa Y. Islama Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
,
Brian Keegana Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Rakhi Tyagi Kundua Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Jungsoon Leea Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Zhuyun Liua Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Jason T. Kimatab Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USAView further author information
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Numan Oezguenc Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA;d Department of Pathology, Texas Children’s Hospital, Houston, TX, USAView further author information
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Jeroen Polleta Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Cristina Povedaa Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Kay Razavia Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Shannon E. Roncaa Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA;b Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USAView further author information
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Ulrich Strycha Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Syamala R. Thimmirajua Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Leroy Versteega Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Maria Jose Villar-Mondragona Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Junfei Weia Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
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Bin Zhana Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAView further author information
&
Maria Elena Bottazzia Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA;b Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USACorrespondence[email protected]
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Pages 495-500 | Received 20 Dec 2022, Accepted 22 May 2023, Published online: 30 May 2023

Figures & data

Figure 1. COVID-19 vaccine development pathway. The stages of vaccine development from the laboratory to the manufacturer. 01. Genetic engineering. 02. Process and assay development. 03. Formulation and pre-clinical strategy. 04. Technology transfer and partnerships. 05. Industrial manufacturing and clinical development.

Figure 1. COVID-19 vaccine development pathway. The stages of vaccine development from the laboratory to the manufacturer. 01. Genetic engineering. 02. Process and assay development. 03. Formulation and pre-clinical strategy. 04. Technology transfer and partnerships. 05. Industrial manufacturing and clinical development.

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