Dysregulation of maternal serum adiponectin in preterm labor

Figures & data

Table I.  Clinical and demographic characteristics of the study population.

	Normal pregnancy (n = 158)	PTL without IAI Term delivery (n = 41)	p*	PTL without IAI preterm delivery (n = 27)	p**	PTL with IAI preterm delivery (n = 36)	p^†
Maternal age (years)	26 (21–31)	23 (19–27)	NS	22 (20–29)	NS	24 (20–28)	NS
Parity	1 (0–2)	2 (1–2)	NS	2 (1–3)	NS	2 (1–3)	NS
First trimester BMI (kg/m^2)	23.1 (21.3–25.9)	23.6 (20.3–29.2)	NS	25.5 (22.3–29.0)	NS	26.6 (23.4–31.1)	NS
GA at blood sampling (weeks)	27.7 (25.3–29.0)	30.0 (26.1–32.2)	NS	31.0 (28.0–32.9)	<0.01	25.4 (24.3–30.8)	<0.05
GA at delivery (weeks)	40.0 (39.0–40.4)	38.3 (37.3–39.4)	<0.01	34.6 (33.7–35.3)	<0.01	26.3 (24.5–31.0)	<0.01
Birth weight (grams)	3465 (3210–3702)	2903 (2697–3267)	<0.01	1940 (1760–2310)	<0.01	815 (628–1645)	<0.01

Values are expressed as median and interquartile (IQR) range; PTL, preterm labor; GA, gestational age; BMI, body mass index; IAI, intra-amniotic infection/inflammation; NS, not significant.

*p: comparison between preterm labor who delivered at term and preterm labor without IAI.

**p: comparison between preterm labor who delivered preterm without IAI and preterm labor with IAI.

^†p: comparison between preterm labor who delivered at term and preterm labor with IAI.

Figure 1. Comparison of the median maternal serum total adiponectin concentrations between women with normal pregnancies and patients with spontaneous PTL. The median maternal serum concentration of total adiponectin was lower in patients with PTL than in those with a normal pregnancy. Among women with PTL, patients with IAI had the lowest median maternal total adiponectin.

Figure 2. Comparison of the median maternal serum HMW adiponectin concentrations between women with normal pregnancies and patients with spontaneous PTL. The median maternal serum concentration of HMW adiponectin was lower in patients with PTL than in those with a normal pregnancy. Among women with PTL, patients with IAI had the lowest median maternal HMW adiponectin.

Figure 3. Comparison of the median maternal serum MMW adiponectin concentration between women with normal pregnancies and patients with spontaneous PTL. The median maternal serum concentration of MMW adiponectin was lower in patients with PTL than in those with a normal pregnancy. Among women with PTL, patients with IAI had lower median maternal MMW adiponectin than patients with PTL who delivered at term.

Figure 4. Comparison of the median maternal serum LMW adiponectin concentrations between women with normal pregnancies and patients with spontaneous preterm labor. The median maternal serum concentration of LMW adiponectin was lower in patients with preterm labor and IAI than in those with a normal pregnancy and than that of those with preterm labor who delivered at term.

Figure 5. Comparison of the median maternal serum HMW/total adiponectin ratios between women with normal pregnancies and patients with spontaneous preterm labor. The median maternal serum HMW/total adiponectin ratio was lower in patients with preterm labor than in those with a normal pregnancy. Among women with preterm labor, patients with IAI had the lowest median maternal HMW/total adiponectin ratio.

Figure 6. Comparison of the median maternal serum MMW/total adiponectin ratio between women with normal pregnancies and patients with spontaneous preterm labor. The median maternal serum MMW/total adiponectin ratio was higher in patients with preterm labor and IAI than in those with a normal pregnancy. The MMW/total adiponectin ratio did not differ significant among the preterm labor groups.

Figure 7. Comparison of the median maternal serum LMW/total adiponectin ratio between women with normal pregnancies and patients with spontaneous preterm labor. The median maternal serum LMW/total adiponectin ratio was higher in patients with preterm labor than in those with a normal pregnancy. LMW/total adiponectin ratio did not differ significant among the preterm labor groups.