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The Journal of Maternal-Fetal & Neonatal Medicine Volume 36, 2023 - Issue 1
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High prevalence of maternal mosaic monosomy X in pregnant women in Vietnam

Danh Cuong Trana Department of Obstetrics and Gynecology, National Hospital of Obstetrics and Gynecology, Hanoi, Vietnam;b Department of Obstetrics and Gynecology Department, Hanoi Medical University, Hanoi, VietnamView further author information
,
Thanh-Thanh Thi Nguyenc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam;d Genetic Counselling, Gene Solutions, Ho Chi Minh City, VietnamView further author information
,
Ngoc-Lan Thi Hoanga Department of Obstetrics and Gynecology, National Hospital of Obstetrics and Gynecology, Hanoi, Vietnam;b Department of Obstetrics and Gynecology Department, Hanoi Medical University, Hanoi, VietnamView further author information
,
Lan-Anh Thi Luongb Department of Obstetrics and Gynecology Department, Hanoi Medical University, Hanoi, VietnamView further author information
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Kim-Phuong Thi Doana Department of Obstetrics and Gynecology, National Hospital of Obstetrics and Gynecology, Hanoi, Vietnam;b Department of Obstetrics and Gynecology Department, Hanoi Medical University, Hanoi, VietnamView further author information
,
Minh Thi Thi Hae Center for Molecular Biomedicine, University of Medicine and Pharmacy, Hue University, Hue, VietnamORCID Iconhttps://orcid.org/0000-0003-3803-9472View further author information
ORCID Icon,
Nhat-Thang Tranf Obstetrics and Gynecology Department, University Medical Center HCMC, Ho Chi Minh City, VietnamView further author information
,
Van-Thong Nguyeng Medical Genetics Department, Hung Vuong Hospital, Ho Chi Minh City, VietnamORCID Iconhttps://orcid.org/0000-0001-9202-1092View further author information
ORCID Icon,
Thu-Huong Nhat Trinhh Department of Antenatal Care, Tu Du Hospital, Ho Chi Minh City, VietnamView further author information
,
Ngoc-Trinh Kieu Nguyenc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam;d Genetic Counselling, Gene Solutions, Ho Chi Minh City, VietnamView further author information
,
Cong-Trai Nguyenc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam;d Genetic Counselling, Gene Solutions, Ho Chi Minh City, VietnamView further author information
,
Thanh-Dat Nguyenc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam;d Genetic Counselling, Gene Solutions, Ho Chi Minh City, VietnamView further author information
,
xQuynh-Tho Thi Nguyenc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, VietnamView further author information
,
Thanh-Thuy Thi Doc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, VietnamView further author information
,
Dinh-Kiet Truongc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, VietnamView further author information
,
Hoa Giangc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam;d Genetic Counselling, Gene Solutions, Ho Chi Minh City, VietnamORCID Iconhttps://orcid.org/0000-0001-6549-8012View further author information
ORCID Icon,
Hoai-Nghia Nguyeni Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamView further author information
,
Hung-Sang Tangc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam;d Genetic Counselling, Gene Solutions, Ho Chi Minh City, VietnamCorrespondence[email protected]
View further author information
&
Minh-Duy Phanc Medical Genetics, Medical Genetics Institutes, Ho Chi Minh City, Vietnam;d Genetic Counselling, Gene Solutions, Ho Chi Minh City, VietnamCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3426-1044View further author information
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Article: 2155044 | Received 30 Aug 2022, Accepted 30 Nov 2022, Published online: 13 Dec 2022

Figures & data

Figure 1. (A) Maternal age distribution of FISH-confirmed MMXO cases compared to normal cases. For visualization purposes, only 500 randomly selected normal cases were plotted. (B) Low correlation between maternal age and percent of maternal XO mosaicism. (C) Strong negative correlation between percent of maternal XO mosaicism and z-scores of ChrX calculated by count-based method (left panel), demonstrating the influence of maternal XO mosaicism, while the triSure method (right panel) is not sensitive to the confounding effect of maternal XO mosaicism.

Figure 1. (A) Maternal age distribution of FISH-confirmed MMXO cases compared to normal cases. For visualization purposes, only 500 randomly selected normal cases were plotted. (B) Low correlation between maternal age and percent of maternal XO mosaicism. (C) Strong negative correlation between percent of maternal XO mosaicism and z-scores of ChrX calculated by count-based method (left panel), demonstrating the influence of maternal XO mosaicism, while the triSure method (right panel) is not sensitive to the confounding effect of maternal XO mosaicism.
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Data availability statement

All data are presented in this manuscript.

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