Obstetrical and neonatal outcomes among pregnancies complicated by hyperparathyroidism

Figures & data

Figure 1. Pregnancies Complicated by Hyperparathyroidism (per 10,000).

Table 1. Baseline Clinical Characteristics of Pregnant Women with and without Hyperparathyroidism, HCUP-NIS 1999-2015.

	Pregnant women with hyperparathyroidism n = 368, %	Pregnant women without hyperparathyroidism n = 13,792,176, %
Age
<25	14.1	33.7
25-34	54.1	51.7
≥35	31.8	14.5
Comorbidities
Diabetes	4.6	0.9
Hypertension	4.4	0.7
Obesity	6.0	1.8
Race
White	51.0	53.0
Black	18.8	13.7
Hispanic	17.1	22.8
Other	13.2	10.5
Income Quartile
Q1	24.4	27.3
Q2	22.2	25.2
Q3	24.7	24.6
Q4	28.8	23.0
Insurance Type
Medicare	3.0	0.5
Medicaid	33.4	40.7
Private	57.3	52.8
Other	6.3	6.0
Hospital Location/Teaching
Rural	4.9	11.6
Urban Non-Teaching	32.1	41.1
Urban Teaching	63.0	47.3

Table 2. Obstetrical Outcomes among Women with Hyperparathyroidism.

	Crude OR (95% CI)	Adjusted OR ^a (95% CI)	Adjusted ^a p-value
Preeclampsia	4.41 (3.32–5.86)	3.14 (2.30–4.28)	<0.0001
Eclampsia	–	–	NS
Placental abruption	1.82 (0.87–3.82)	1.60 (0.75–3.37)	NS
VTE	4.14 (1.34–12.73)	2.32 (0.74–7.27)	NS
MI	–	–	NS
PPH	0.85 (0.44–1.65)	0.80 (0.41–1.55)	NS
Transfusion	2.02 (0.91–4.47)	1.46 (0.65–3.28)	NS
DIC	–	–	NS
Maternal death	–	–	NS
Cesarean delivery	2.19 (1.78–2.70)	1.69 (1.36–2.09)	<0.0001

VTE: venous thromboembolism; MI: myocardial infarction; PPH: post-partum hemorrhage; DIC: disseminated intravascular coagulation; OR: odds ratio; CI: confidence interval; NS: not statistically significant.

^aAdjusted for variables listed in Table 1.

Table 3. Neonatal Outcomes among Births to Women with Hyperparathyroidism.

	Crude OR (95% CI)	Adjusted OR^a (95% CI)	Adjusted^a p-value
Preterm delivery	2.05 (1.52–2.77)	1.69 (1.24–2.29)	<0.001
FGR	2.07 (1.24–3.48)	1.83 (1.08–3.07)	0.02
Congenital anomalies	5.13 (2.55–10.32)	4.21 (2.09–8.48)	<0.0001
IUFD	0.82 (0.21–3.26)	0.64 (0.16–2.57)	NS

FGR: fetal growth restriction; IUFD: intrauterine fetal demise; OR: odds ratio; CI: confidence interval; NS: not statistically significant.

^aAdjusted for variables listed in Table 1.