Evaluation of maternal serum SERPINC1, E-selectin, P-selectin, RBP4 and PP13 levels in pregnancies complicated with preeclampsia

Figures & data

Table 1. Evaluation of the groups in terms of maternal and perinatal parameters.

	PE Group (n = 40)	Control group (n = 40)	p
Age (years) Mean±SD	26.9 ± 5.42 (26)	30.2 ± 5.01 (30.5)	^a.006*
Nulliparity n (%)	17 (%42.5)	12 (%30)	^c.352
SBP (mmHg) Mean±SD (median)	148.13 ± 6.47 (145)	111 ± 12.41 (110)	^b.000*
DBP (mmHg) Mean±SD (median)	97 ± 5.86 (95)	70.13 ± 8.12 (70)	^b.000*
Gestational age at blood sampling (weeks) Mean±SD (median)	32.75 ± 2.23 (33)	33.48 ± 3 (34)	^b.295
Gestational age at blood sampling (days) Mean±SD (median)	3.45 ± 1.75 (3)	3.55 ± 1.88 (4)	^b.788
PE history n (%)	3 (%7.5)	1 (%2.5)	^d.615
Severe PE n (%)	3 (%7.5)	0 (%0)	^d.241
HELLP Syndrome n (%)	2 (%5)	0 (%0)	^d.494
Eclampsia n (%)	1 (%2.5)	0 (%0)	^d1.000
Gestational age at delivery (weeks) Mean±SD (median)	36.8 ± 1.04 (37)	38.73 ± 1.52 (39)	^b.000*
Gestational age at delivery (days) Mean±SD (median)	3.08 ± 2.22 (3)	2.73 ± 2.33 (2.5)	^b.437
Birth Weight Mean±SD (median)	2705.5 ± 255.53 (2635)	3214.38 ± 390 (3215)	^a.000*
IUMF n (%)	1 (%2.5)	0 (%0)	^d1.000
C/S	16 (%40)	12 (%30)	^c.482
NSD	24 (%60)	28 (%70)
Apgar 1st minute Mean±SD (median)	7.40 ± 1.86 (8)	8.45 ± 1.06 (9)	^b.001*
Apgar 5th minute Mean±SD (median)	8.68 ± 1.83 (9)	9.6 ± 0.67 (10)	^b.004*
NICU Need	13 (%32.5)	4 (%10)	^c.029*
Proteinuria (mg/24h) n (%)	8 (%20)	0 (%0)	^4.005*
ALT (U/L) Mean±SD (median)	23.2 ± 24.94 (15.5)	19.33 ± 12.07 (17.5)	.855
AST (U/L) Mean±SD (median)	22.3 ± 12.82 (21)	19.73 ± 6.38 (18.5)	.569
Creatinine (mg/dL) Mean±SD (median)	0.71 ± 0.23 (0.7)	0.65 ± 0.1 (0.6)	.550
BUN (mg/dL) Mean±SD (median)	19.66 ± 7.55 (19)	17.31 ± 4.36 (17)	.256
LDH (U/L) Mean±SD (median)	192.9 ± 33.14 (187.5)	198.55 ± 22.36 (202)	.047*
Platelet count (10^3/uL) Mean±SD (median)	247,775 ± 97,063.15 (248,000)	267,275 ± 53,790.66 (272,000)	^+.271

SBP: Systolic blood pressure; DBP: Diastolic blood pressure; PE: Preeclampsia; HELLP: Hemolysis; Elevated Liver enzymes and Low Platelet; IUMF: Inutero mort fetalis; C/S: Cesarean Section; NSD: Normal Spontaneous Delivery; NICU: Neonatal Intensive Care Unit; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen; LDH: Lactate dehydrogenase.

^a+Student’s t-test

^bMann –Whitney U Test

^cContinuity (yates) düzeltmesi

^dFisher’s Exact Test *p < .05.

Table 2. Evaluation of the groups in terms of biomarkers.

	PE Group (n = 40)	Control Group (n = 40)
	Mean ± SD (median)	Mean ± SD (median)	p
E-SELECTIN (ng/ml)	45.92 ± 24.03 (39.9)	9.31 ± 5.78 (7.1)	.000*
P-SELECTIN (ng/ml)	38.08 ± 24.16 (31.8)	2.03 ± 0.9 (1.9)	.000*
RBP4 (ng/ml)	1.93 ± 0.29 (2)	1.95 ± 0.25 (2)	.712
PP13 (pg/ml)	114.71 ± 50.18 (96.5)	217.79 ± 156.51 (191)	.000*
SERPINC1 (ng/ml)	45.62 ± 18.59 (36.5)	124.66 ± 22.49 (126.3)	.000*

Mann–Whitney U Test, *p < .05.

Table 3. Evaluation of biomarkers according to the presence of proteinuria in the preeclampsia group.

	Proteinuria
	No (n = 32)	Yes (n = 8)
	Mean ± SD (median)	Mean ± SD (median)	p
E-SELECTIN	42.62 ± 22.74 (35.9)	59.1 ± 26.03 (54.4)	.098
P-SELECTIN	37.94 ± 22.95 (32.7)	38.68 ± 30.34 (29.6)	.866
RBP4	1.91 ± 0.28 (1.9)	2.01 ± 0.33 (2.1)	.286
PP13	113.68 ± 50.5 (96.1)	118.81 ± 52.05 (109.9)	.542
SERPINC1	44.44 ± 18.42 (35.9)	50.35 ± 19.78 (54.2)	.600

Mann–Whitney U Test, *p < 0.05.

Figure 1. ROC curve to predict preeclampsia (PE) based on biomarkers of endothelial dysfunction.