Placenta-mediated pregnancy complications in women with a history of late fetal loss and placental infarction without thrombophilia: risk of recurrence and efficacy of pharmacological prophylactic interventions. A 10-year retrospective study

Figures & data

Table 1. Baseline characteristics of analyzed patients.

	ASA + LMWH N. 73	ASA N. 55	p
Maternal age	33 (SD 5.29 SEM 0.62)	33 (SD 4.71 SEM 0.63)	–
Pre-pregnancy BMI	24.9 (SD 4.52 SEM 0.53)	26 (SD 5.39 SEM 0.73)	–
Mean gestational age of previous maternal loss	35 (SD 4.2 SEM 0.61)	36 (SD 5.6 SEM 0.70)	–
BMI >30 %	13	19	0.335
Previous miscarriage <12 weeks (N)	30	21	0.02
Family history of thromboembolic events*	10	6	0.63
Current smoker (N)	3	4	–
Race/ethnic group (N)	White 71 Black African 2	White 53 Black African 2	–

*Only first degree parents were considered.

Table 2. Analysis of maternal and fetal outcomes in the whole series and according to treatment.

Maternal outcome	Total N. 128 N. %		ASA + LMWH N. 73 N. %		ASA N. 55 N. %		RR 95%CI P
Delivery <37 ° weeks	32	25	16	22	16	29	0.85	0.46–1.56	0.615
<34 ° weeks	7	5	1	1.3	6	11	0.11	0.01–0.95	0.045
Early/severe preeclampsia	6	5	1	1.3	5	10	0.14	0.01–1.18	0.071
Placental abruption	8	6	3	4	5	10	0.42	0.10–1.70	0.229
Cesarean Section	80	62	44	60	36	65	–	–	–
Pregnancy-related thrombosis	0	0	0	–	0	–	–	–	–
Fetal outcome
Weight <2500 g.	23	18	12	16	11	20	0.77	0.37–1.62	0.504
SGA <10° percentile	6	5	4	6	2	4	1.42	0.27–7.49	0.676
SGA <5° percentile	5	4	4	6	1	2	2.85	0.32–24.8	0.341
Miscarriages <20 weeks	3	2	0	0	3	5	0.10	0.00–2.05	0.138
Fetal losses >20 weeks	8	6	3	4	5	10	0.45	0.11–1.81	0.262
Mean birth weight g (SD)	2834 (525)		2854 (495)		2813 (692)		–		0.63
Weeks at Delivery (SD)	37.1 (1.88)		37.3 (1.56)		37.1 (2.35)		–		0.58