Fetal brain imaging provides valuable information in cCMV infected infants

Figures & data

Table 1. Demographic and clinical characteristics of cases with confirmed cCMV.

Patient characteristics	Patients (N = 10)
	Count (%)
Gestational Age at birth (weeks)
≤30	1 (10)
30–35	0 (0)
40–42	9 (90)
≥ 42	0 (0)
Gender
Female	6 (70)
Male	4 (40)
Maternal Age (years)
≤30	2 (20)
30–35	3 (30)
36–39	4 (40)
≥40	1 (10)
Gestational Age during fetal MRI (weeks)
23–25	1 (10)
26–30	6 (60)
≥30	3 (30)
Age during neonatal MRI
1st month of life	7 (70)
2nd month of life	2 (20)
3rd month of life	1 (10)
Trimester of seroconversion
1st	8 (80)
2nd	2 (20)
3rd	0 (0)

Table 2. Agreement between two accredited radiologists regarding the presence or absence of abnormalities in fetal and neonatal MRIs.

MRI	FETAL MRI					NEONATAL MRI
Abnormalities	Concordance (%)	Abnormality reported within concordance group		Non Concordance group	Concordance (%)	Abnormality reported within concordance group		Non Concordance group
		Present (%)	Not present (%)	Inconclusive (%)		Present (%)	Not present (%)	Inconclusive (%)
Ventricular Dilatation	10 (100)	2 (20)	8 (80)	0(0)	10 (100)	0 (0)	10 (100)	0 (0)
Calcifications	10 (100)	0 (0)	10 (100)	0 (0)	10 (100)	2 (20)	8 (80)	0 (0)
Abnormal White Matter T2 Hyperintensity (Parieto-occipital)	10 (100)	4 (40)	6 (60)	0 (0)	10 (100)	2 (20)	8 (80)	0 (0)
Temporal Horn Dilatation	10 (100)	0 (0)	10 (100)	0 (0)	10 (100)	5 (50)	5 (50)	0 (0)
Cerebellar Abnormalities	10 (100)	0 (0)	10 (100)	0 (0)	10 (100)	0 (0)	10 (100)	0 (0)
Temporal/Occipital lobe cysts	10 (100)	3 (30)	7 (70)	0 (0)	10 (100)	5 (50)	5 (50)	0 (0)
Microcephaly	10 (100)	0 (0)	10 (100)	0 (0)	10 (100)	2 (20)	8 (80)	0 (0)
Microencephaly	10 (100)	0 (0)	10 (100)	0 (0)	10 (100)	2 (20)	8 (80)	0 (0)
Cerebellar Hypoplasia	10 (100)	0 (0)	10 (100)	0 (0)	10 (100)	0 (0)	10 (100)	0 (0)
Ventricular Adhesions	8 (80)	2 (20)	6 (60)	2 (20)	10 (100)	0 (0)	10 (100)	0 (0)
Subependymal Cysts	8 (80)	2 (20)	6 (60)	2 (20)	9 (90)	0 (0)	9 (100)	1 (10)
Ventricular Adhesions Temporal/Occipital Lobe	8 (80)	1 (10)	7 (70)	2 (20)	9 (90)	2 (20)	7 (70)	1 (10)
Abnormal White Matter T2 Hyperintensity (Temporal)	6 (60)	4 (40)	2 (20)	4 (40)	9 (90)	2 (20)	7 (70)	1(10)
Gyral Abnormalities	5 (50)	0 (0)	5 (50)	5 (50)	9 (90)	0 (0)	9 (100)	1(10)

Table 3. Concordance between the radiologic findings of fetal and neonatal MRIs for each patient.

Patient	MRI	Scan Outcome	Neonatal Antiviral Treatment
1	Fetal	Abnormal concordant	Yes
	Neonatal	Abnormal concordant
	Fetal vs Neonatal	Abnormal fetal + neonatal
2	Fetal	Abnormal concordant	No
	Neonatal	Normal concordant
	Fetal vs Neonatal	Non-concordant
3	Fetal	Abnormal concordant	No
	Neonatal	Abnormal concordant
	Fetal vs Neonatal	Abnormal fetal + neonatal
4	Fetal	Abnormal concordant	Yes
	Neonatal	Abnormal concordant
	Fetal vs Neonatal	Abnormal fetal + neonatal
5	Fetal	Abnormal concordant	No
	Neonatal	Normal concordant
	Fetal vs Neonatal	Non-concordant
6	Fetal	Abnormal concordant	Yes
	Neonatal	Abnormal concordant
	Fetal vs Neonatal	Abnormal fetal + neonatal
7	Fetal	Non-concordant	No
	Neonatal	Normal concordant
	Fetal vs Neonatal	Non-concordant
8	Fetal	Abnormal concordant	No
	Neonatal	Abnormal concordant
	Fetal vs Neonatal	Abnormal fetal + neonatal
9	Fetal	Abnormal concordant	Yes
	Neonatal	Abnormal concordant
	Fetal vs Neonatal	Abnormal fetal + neonatal
10	Fetal	Abnormal concordant	No
	Neonatal	Abnormal concordant
	Fetal vs Neonatal	Abnormal fetal + neonatal