Evaluation of serum levels of soluble vascular endothelial (sVE)-Cadherin in early- and late-onset preeclampsia serum sVE-Cadherin levels in preeclampsia

Figures & data

Table 1. Demographic, clinical and laboratory features of the women with EOPE and women in the control group GA-matched for EOPE.

	EOPE (n = 60)		Control Group GA-matched for EOPE (n = 60)
	Mean± SD	Median (25–75%)	Mean ± SD	Median (25–75%)	p	Test
Age (years)	29.4 ± 4.5	30 (26–33)	27.8 ± 3.9	27 (25–29)	0.51	T-test
BMI (kg/m^2)	29.3 ± 3.9	30.1 (27.1–32.7)	28.2 ± 3.6	27.6 (25.6–30.8)	0.102	T-test
Parity (n)	0.83 ± 1.1	0 (0–1)	0.98 ± 1.0	1 (0–1)	0.815	MWU
Systolic ABP (mm/Hg)	160 ± 15	160 (150–170)	113 ± 13	115 (109–120)	<0.001	MWU
Diastolic ABP (mm/Hg)	102 ± 10	100 (92–110)	72 ± 9	75 (66–80)	<0.001	MWU
GA at sampling (w)	28.2 ± 3.1	28 (26–31)	28.7 ± 3.1	29 (26–32)		MWU
GA at birth (w)	30.9 ± 3.7	31 (28–34)	38.26 ± 1.6	38 (38–40)
WBC (10^9/L)	12.0 ± 2.9	11.9 (9.9–14.5)	10.34 ± 2.5	9.85 (8.83–10.93)	0.004	T-test
Platelet count (10^3/µL)	200 ± 69	210 (146–259)	221 ± 59	202 (176–266)	0.099	T-test
Creatinine (mg/dL)	0.64 ± 0.15	0.64 (0.50–0.75)	0.51 ± 0.1	0.5 (0.4–0.6)	<0.001	T-test
Total bilirubin (mg/dL)	0.32 ± 0.17	0.26 (0.22–0.38)	0.41 ± 0.3	0.34 (0.23–0.42)	0.192	MWU
Uric acid (mg/dL)	5.5 ± 1.3	5.6 (5.0–6.3)	3.8 ± 0.9	3.8 (3.0–4.1)	<0.001	T-test
Urea (mg/dL)	24.2 ± 10.1	22.5 (18–28.7)	12.2 ± 4.3	11 (9–15)	<0.001	MWU
AST (IU/L)	34.6 ± 40.5	18 (11–38)	12.5 ± 5.4	13 (9–17)	0.099	MWU
ALT (IU/L)	36.4 ± 52.1	14 (9–32)	11.5 ± 4.4	10 (8–13)	0.207	MWU
sVE-Cadherin (ng/mL)	5.86 ± 1.57	5.56 (4.42–7.01)	2.28 ± 0.80	2.38 (1.71–2.77)	<0.001	T-test

ABP: arterial blood pressure; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body-mass-index; GA: gestational age; SD: standard deviation; sVE-Cadherin: soluble vascular endothelial cadherin; WBC: white blood cells.

p < 0.05 is significant (marked with bold).

MWU: Mann-Whitney-U Test.

Table 2. Demographic, clinical and laboratory features of the women with LOPE and women in the control group GA-matched for LOPE.

	LOPE (n = 60)		Control Group GA-matched for LOPE (n = 60)
	Mean± SD	Median (25–75%)	Mean±SD	Median (25–75%)	p	Test
Age (years)	28.7 ± 5.7	30 (23–33)	28.1 ± 6.2	27 (24–33)	0.574	T-test
BMI (kg/m^2)	31.2 ± 4.7	30.8 (28.2–34.1)	30.5 ± 4.9	30.6 (26.6–33.4)	0.447	T-test
Parity (n)	0.9 ± 1.3	0 (0–1.7)	1.12 ± 0.9	1 (0–2)	0.815	MWU
Systolic ABP (mm/Hg)	152 ± 12	150 (149–160)	113 ± 12	112 (105–125)	<0.001	MWU
Diastolic ABP (mm/Hg)	96 ± 7	90 (90–100)	74 ± 12	75 (65–85)	<0.001	MWU
GA at sampling (w)	36.3 ± 1.7	36 (35–38)	36.9 ± 1.6	37 (36–38)	0.091	T-test
GA at birth (w)	37.5 ± 1.4	38 (37–38)	38.6 ± 1.2	38.5 (38–39)
WBC (10^9/L)	10.5 ± 2.6	10.0 (8.9–12.1)	11.3 ± 3.0	10.4 (9.0–12.8)	0.150	T-test
Platelet count (10^3/µL)	207 ± 68	187 (154–256)	228 ± 66	226 (181–276)	0.097	T-test
Creatinine (mg/dL)	0.61 ± 0.14	0.6 (0.50–0.7)	0.53 ± 0.12	0.53 (0.43–0.62)	0.002	T-test
Total bilirubin (mg/dL)	0.52 ± 1.39	0.30 (0.19–0.43)	0.37 ± 0.20	0.32 (0.20–0.48)	0.230	T-test
Uric acid (mg/dL)	5.25 ± 1.24	5.3 (4.47–6.2)	4.03 ± 0.86	4.03 (3.45–4.54)	<0.001	MWU
Urea (mg/dL)	18.48 ± 6.98	18 (14–22)	14.75 ± 5.2	13 (11–17)	0.005	MWU
AST (IU/L)	15.37 ± 10.3	12 (10–17)	13.1 ± 6.4	12 (10–17)	0.353	MWU
ALT (IU/L)	13.25 ± 11.6	11 (8–14)	12.6 ± 7.8	10 (7–14)	0.332	MWU
sVE-Cadherin (ng/mL)	3.11 ± 0.97	2.95 (2.23–3.98)	1.69 ± 0.87	1.66 (1.05–2.35)	<0.001	T-test

ABP: arterial blood pressure; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body-mass-index; GA: gestational age; SD: standard deviation; sVE-Cadherin: soluble vascular endothelial cadherin; WBC: white blood cells.

p < 0.05 is significant (marked with bold).

MWU, Mann-Whitney-U test.

Figure 1. Scatterplot analysis of the correlation between sVE-Cadherin and gestational age. The circles show the mean sVE-Cadherin value for that pregnancy week.

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article [and/or] its supplementary materials.