https://orcid.org/0000-0002-7141-4265
Figures & data
Figure 1. Study overview.
SGABD, gestational age at blood draw; miPTB, medically indicated preterm birth; PTB, preterm birth; sPTB, spontaneous preterm birth.
Table 1. Maternal characteristics and pregnancy outcomes in the Viet Nam study cohort.
Table 2. Performance of the IGFBP4/SHBG predictor alone and when applying the clinical ObRisk factor, evaluated for preterm births at <37 and <34 weeks’ gestation.
Figure 2. Calibration plots for (a) IGFBP4/SHBG and (b) IGFBP4/SHBG + ObRisk.
CI, confidence interval; IGFBP4, insulin-like growth factor-binding protein 4; ObRisk, a dichotomous clinical factor based on prior miscarriage (nulliparas) or prior preterm birth (multiparas); SHBG, sex hormone-binding globulin.
Figure 3. Kaplan-Meier plots of gestational age at birth for subjects evaluated to be at lower or higher PTB risk, stratified by (a) IGFBP4/SHBG ratio and (b) IGFBP4/SHBG ratio + ObRisk, at a screen-positive rate of 20%.
IGFBP4, insulin-like growth factor-binding protein 4; ObRisk, clinical factor based on prior miscarriage (nulliparas) or prior preterm birth (multiparas); SHBG, sex hormone binding globulin.
Table 3. IGFBP4/SHBG + ObRisk predictor performance for all-cause preterm birth under selected testing scenarios in combined cohorts A, B, and C.
Supplemental Material
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Data supporting the findings of this study are present in the paper and/or the Supplemental Materials. Additional data related to this paper may be requested from the authors.