Analysis of long-term outcome of image-guided volumetric modulated arc therapy (VMAT) for primary malignant tumor of the cervical spine

Figures & data

Table 1. General information of patients (n = 28).

	Quantity	Percent (%)
Median age	42 (12～71)
Gender
Male	13	46.4
Female	15	53.6
KPS score
70	6	21.4
80	13	46.4
90	8	28.6
100	1	3.6
Pathological type of tumors
Chordoma	14	50.0
Giant cell tumor of bone	9	32.1
Sarcoma	4	14.3
Schwannoma	1	3.6
Prior treatment
Primary	14	50
Postoperative residual	5	17.9
Postoperative recurrence	9	32.1
Median follow-up time (month)	53 (6～76)

Table 2. General information of patients (n = 28).

No.	Gender	Age	Pathological type	Position	PGTVRT dose	NRS	Frankel Grade
1	M	12	Ewing sarcoma	C2	RT45 Gy/20 f	2-3	E
2	M	39	Hemangiosarcoma	C1-4	S+ RT 66 Gy/33 f	2	E
3	F	21	Hemangiosarcoma	C2-3	RT50 Gy/20 f	4-5	E
4	F	71	Schwannomaaganglioma	C5-6	RT60 Gy/30 f	4-6	E
5	M	45	Chordoma	C2	RT62.1 Gy/27 f	3-4	E
6	M	47	Chordoma	C3-5	S+ RT62.1 Gy/27 f	2	D
7	M	31	Chordoma	C1-3	RT60 Gy/22 f	4	E
8	M	23	Giant cell tumor of bone	C2-3	S+ RT60 Gy/22 f	2	E
9	F	24	Giant cell tumor of bone	C4-T1	RT60 Gy/22 f	5-6	E
10	F	38	Giant cell tumor of bone	C1-6	RT60 Gy/22 f	3-4	E
11	F	42	Giant cell tumor of bone	C2-7	RT50 Gy/20 f	0	E
12	F	56	Chordoma	C2	RT62.1 Gy/27 f	3	E
13	M	60	Chordoma	C4	RT60 Gy/22 f	1	E
14	M	50	Chordoma	C2	RT62.1 Gy/27 f	2	E
15	M	44	Chordoma	C2	S+ RT66 Gy/33 f	0	E
16	F	35	Chordoma	C1-4	S+ RT60 Gy/25 f	0	E
17	F	32	Chordoma	C2-6	S+ RT62.1 Gy/27 f	5-7	E
18	F	52	Chordoma	C2	RT62.1 Gy/27 f	3-4	E
19	F	44	Chordoma	C1-2	RT60 Gy/22 f	5	E
20	F	50	Chordoma	C2	S+ RT60 Gy/22 f	2	E
21	F	14	Chordoma	C4-7	S+ RT60 Gy/22 f	2	E
22	F	39	Chordoma	C2	RT62.1 Gy/27 f	5-6	E
23	M	65	Osteosarcoma	C5-7	S+ RT60 Gy/25 f	2	E
24	M	29	Giant cell tumor of bone	C2-5	S+ RT60 Gy/22 f	1	E
25	F	25	Giant cell tumor of bone	C2	S+ RT60 Gy/22 f	0	E
26	F	58	Giant cell tumor of bone	C3-T1	S + S+ RT60 Gy/22 f	3	E
27	M	23	Giant cell tumor of bone	C5-7	S+ RT55 Gy/22 f	0	E
28	M	42	Giant cell tumor of bone	C1-2	S+ RT55 Gy/22 f	0	E

S = surgery, RT = radiotherapy, M = male, F = female, C = cervical vertebra.

Table 3. NRS score of 22 patients before and after RT.

NRS score before RT	Number of cases	NRS score at the last follow-up
		CR	Improved	Not-improved	Aggravated
Mild (1–3 point)	12	8	4	0	0
Moderate (4–6 point)	9	3	4	2	0
Severe (7–9 point)	1	0	1	0	0

Table 4. Grading of RT acute complications for 28 patients (CTCAE V4.0).

	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Myelosuppression	3	2	0	0	0
Radiodermatitis	11	0	0	0	0
Nausea	6	4	0	0	0
Anorexia	6	4	0	0	0
Dysphagia	15	4	0	0	0
Oropharyngeal mucosa reaction	15	9	0	1	0