The Glittre-ADL Test Cut-Off Point to Discriminate Abnormal Functional Capacity in Patients with COPD

Figures & data

Table 1. Anthropometric characteristics, pulmonary function, dyspnea, quality of life, health status, functional status, and physical activities of daily life of the sample.

Variables	Mean ± SD	6 MWT < 82% pred, Mean ± SD (n = 36)	6 MWT > 82% pred, Mean ± SD (n = 23)	p
Sex (male/female)	45/14^b	27/9^b	18/5^b	0.77
LTOT	5^b	4^b	1^b	—
Age (years)	65.5 ± 8.84	67 ± 9.05	62.3 ± 8.09	0.02
Body weight (kg)	72.8 ± 15.32	74.7 ± 15.7	70.4 ± 14.7	0.41
Height (m)	1.66 ± 0.1	1.68 ± 0.10	1.67 ± 0.10	0.89
BMI (kg/m^2)	26 ± 4.78	26.6 ± 4.68	25.4 ± 5.18	0.42
Pack-years	55.6 ± 32.9	62.6 ± 35.5	45.0 ± 25.8	0.03
FEV1/FVC	0.44 ± 0.09	0.42 ± 0.10	0.49 ± 0.08	0.006
FEV1 (L)	1.08 ± 0.46	0.96 ± 0.44	1.26 ± 0.46	0.008
FEV1 (%pred)	35.3 ± 13.4	32.0 ± 13.1	40.2 ± 13.3	0.01
FVC (L)	2.35 ± 0.76	2.24 ± 0.68	2.52 ± 0.90	0.14
FVC (%pred)	60.8 ± 16.0	57.9 ± 15.9	65.1 ± 16.2	0.09
TGlittre (min)	4.56 ± 2.15	5.52 ± 2.36	3.14 ± 0.37	<0.001
6 MWT (m)	437 ± 95.4	380 ± 62.5	526 ± 67.4	<0.001
6 MWT (%pred)	77.9 ± 14.7	69.0 ± 10.6	91.8 ± 8.62	<0.001
mMRC	1 [1]^a	2 [2]^a	1 [0]^a	<0.001
CAT (total)	16.9 ± 7.96	19.8 ± 7.61	12.6 ± 6.57	<0.001
SGRQsymptoms	37.7 ± 20.8	46.0 ± 20.0	26.3 ± 16.3	<0.001
SGRQactivity	65.7 ± 20.8	72.4 ± 19.9	56.1 ± 19.1	0.003
SGRQimpact	36.7 ± 21.0	42.9 ± 22.4	28.7 ± 15.5	0.02
SGRQtotal	45.7 ± 19.1	52.5 ± 19.3	36.6 ± 14.4	0.001
BODE index (score)	3.4 ± 1.82	4.06 ± 1.97	2.50 ± 1.06	0.002
Time sitting (min)	380.5 ± 106.6	394 ± 112	360 ± 96.0	0.24
Time lying (min)	107.3 ± 106.8	107 ± 113	108 ± 98.3	0.89
Time standing (min)	140.8 ± 56.5	137 ± 56.5	146 ± 58.2	0.58
Time walking (min)	68.5 ± 39.0	58.6 ± 30.5	84.4 ± 46.0	0.03
Number of steps taken	5,314 ± 2,766	4,534 ± 2,422	6,545 ± 2,876	0.006
Time in activities < 1.5 MET (min)	583.7 ± 68.6	601 ± 50.9	557 ± 84.4	0.05
Time in activities ≥ 3 METs (min)	84.3 ± 41.9	74.5 ± 33.0	100 ± 50.1	0.02

BMI, body mass index; CAT, COPD assessment test; FEV₁, forced expiratory volume in 1 s; FVC, forced vital capacity; kg, kilograms; L, liter; LTOT, long-term oxygen therapy; m, meters; MET, metabolic equivalent of task; min, minutes; mMRC, modified Medical Research Council scale; 6 MWT, six-minute walk test; %pred, percentage of predicted; SD, standard deviation; SGRQ, Saint George's Respiratory Questionnaire; and TGlittre, ADL-Glittre test.

^a Results are presented as median (interquartile range).

^b Results are presented as frequency.

Table 2. Anthropometric characteristics, pulmonary function, dyspnea, quality of life, health status, functional status, and physical activities of daily life of the patients with TGlittre ≤3.5 minutes and TGlittre >3.5 minutes.

	TGlittre	TGlittre
	≤3.5 min,	>3.5 min,
	Mean ± SD	Mean ± SD
Variables	(n = 22)	(n = 37)	p
Sex (male/female)	15/7^b	30/7^b	0.26
LTOT	1^b	4^b	—
Age (years)	60.3 ± 7.23	68.5 ± 8.34	<0.001
Body weight (kg)	68.3 ± 14.4	75.5 ± 15.4	0.082
Height (m)	1.65 ± 0.10	1.68 ± 0.09	0.33
BMI (kg/m^2)	25.0 ± 5.02	26.7 ± 4.6	0.19
Pack-years	46.4 ± 25.7	61.0 ± 35.7	0.16
FEV1/FVC	0.47 ± 0.10	0.43 ± 0.10	0.08
FEV1 (L)	1.22 ± 0.48	1.00 ± 0.43	0.07
FEV1 (%pred)	39.7 ± 13.5	32.7 ± 12.9	0.06
FVC (L)	2.50 ± 0.90	2.26 ± 0.67	0.27
FVC (%pred)	65.2 ± 16.2	58.2 ± 15.4	0.10
TGlittre (min)	3.07 ± 0.30	5.45 ± 2.30	<0.001
6 MWT (m)	520 ± 73.7	388 ± 69	<0.001
6 MWT (%pred)	90.0 ± 10.4	70.7 ± 11.9	<0.001
mMRC	1 [0]^a	2 [2]^a	0.001
CAT (total)	14.0 ± 6.60	18.5 ± 8.30	0.03
SGRQsymptoms	28.4 ± 17.1	43.3 ± 21.0	0.007
SGRQactivity	57.1 ± 17.6	70.8 ± 21.1	0.01
SGRQimpact	30.5 ± 15.7	40.4 ± 23.0	0.06
SGRQtotal	38.1 ± 14.0	50.2 ± 20.4	0.009
BODE index (score)	2.55 ± 1.18	3.92 ± 1.95	0.001
Time sitting (min)	342.9 ± 105.2	402.4 ± 102.6	0.004
Time lying (min)	123.9 ± 104.6	97.6 ± 109.3	0.42
Time standing (min)	149.6 ± 59.7	135.7 ± 54.7	0.37
Time walking (min)	82.5 ± 46.8	60.4 ± 31.5	0.08
Number of steps taken	6,292 ± 2,925	4,743 ± 2,537	0.004
Time in activities < 1.5 MET (min)	553.4 ± 86.0	601.4 ± 49.4	0.04
Time in activities ≥ 3 METs (min)	99.5 ± 50.9	75.5 ± 33.4	0.07

BMI, body mass index; CAT, COPD assessment test; FEV₁, forced expiratory volume in 1 s; FVC, forced vital capacity; kg, kilograms; L, liter; LTOT, long-term oxygen therapy; m, meters; MET, metabolic equivalent of task; min, minutes; mMRC, modified Medical Research Council scale; 6 MWT, six-minute walk test; %pred, percentage of predicted; SD, standard deviation; SGRQ, Saint George Respiratory Questionnaire; and TGlittre, ADL-Glittre test.

^a Results are presented as median (interquartile range).

^b Results are presented as frequency.

Figure 1. Receiver operating characteristic (ROC) curve for the cut-off point of time spent on the TGlittre to discriminate patients with abnormal (distance walked on the 6-minute walk test < 82% pred) and normal (distance walked on the 6-minute walk test ≥ 82% pred) functional capacity. Cut-off point = 3.5 minutes; sensitivity = 92%; specificity = 83%; and area under the ROC curve = 132 meters, 95% CI: 94.1–170 meters.