Restricting retrotransposons: ADAR1 is another guardian of the human genome

Figures & data

Figure 1. Possible models for how ADAR1 inhibits LINE-1 retrotransposition. (A) L1 RNAs are edited by ADAR1 causing nucleotide changes in the ORF sequence or altering the dsRNA elements harbored within L1 RNAs. (B) ADAR1 by binding the basal L1 RNP complex and/or its associated proteins impairs its functionality. (C) ADAR1 sequesters L1 RNP complexes in the stress granules. (D) ADAR1 binds L1 DNA/RNA hybrids during the RT step of the L1 life cycle and either impairs the formation of these hybrids or edits the DNA.