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Journal of the International Society of Sports Nutrition Volume 20, 2023 - Issue 1
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Research Article

Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults

Shiloah A. Kviatkovskya Florida State University, Department of Nutrition and Integrative Physiology, Tallahassee, FL, USA;b Florida State University, Institute of Sports Sciences and Medicine, Tallahassee, FL, USA;c University of Arkansas for Medical Sciences, Center for Aging and Longevity, Geriatrics, Little Rock, AR, USAORCID Iconhttps://orcid.org/0000-0002-1775-2917View further author information
ORCID Icon,
Robert C. Hicknera Florida State University, Department of Nutrition and Integrative Physiology, Tallahassee, FL, USA;b Florida State University, Institute of Sports Sciences and Medicine, Tallahassee, FL, USA;f University of KwaZulu-Natal, School of Health Sciences, Discipline of Biokinetics, Exercise and Leisure Sciences, Durban, South AfricaView further author information
,
Hannah E. Cabred The University of North Carolina at Chapel Hill, Applied Physiology Lab, Department of Sport Science, Chapel Hill, NC, USAView further author information
,
Stephanie D. Smalle University of Toronto, Faculty of Kinesiology & Physical Education, Toronto, ON, CanadaView further author information
&
Michael J. Ormsbeea Florida State University, Department of Nutrition and Integrative Physiology, Tallahassee, FL, USA;b Florida State University, Institute of Sports Sciences and Medicine, Tallahassee, FL, USA;f University of KwaZulu-Natal, School of Health Sciences, Discipline of Biokinetics, Exercise and Leisure Sciences, Durban, South AfricaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1939-7656View further author information
ORCID Icon
Article: 2243252 | Received 22 Feb 2023, Accepted 25 Jul 2023, Published online: 08 Aug 2023

Figures & data

Figure 1. Flowchart of participant recruitment, dropouts, and randomization before and during study intervention. CP = collagen peptides, g = grams, d = day.

Figure 1. Flowchart of participant recruitment, dropouts, and randomization before and during study intervention. CP = collagen peptides, g = grams, d = day.

Table 1. Baseline characteristics for participants who completed the 6-month and 9-month arm of the study intervention.

Table 2. Average macronutrient and energy intake from baseline to 6 months.

Figure 2. (a) Differences between treatment groups in KOOS ADLs at baseline, 3 months, and 6 months, with reported p-value for group by time interaction. (b) Differences between low frequency exercisers in treatment groups in KOOS Pain at baseline, 3 months, and 6 months. (c) Differences between high frequency exercisers in treatment groups in KOOS Pain at baseline, 3 months, and 6 months. AU = arbitrary units, g = grams, d = day, ADLs = activities of daily living, KOOS = Knee injury and Osteoarthritis Outcome Score, LF = low frequency, HF = high frequency.

Figure 2. (a) Differences between treatment groups in KOOS ADLs at baseline, 3 months, and 6 months, with reported p-value for group by time interaction. (b) Differences between low frequency exercisers in treatment groups in KOOS Pain at baseline, 3 months, and 6 months. (c) Differences between high frequency exercisers in treatment groups in KOOS Pain at baseline, 3 months, and 6 months. AU = arbitrary units, g = grams, d = day, ADLs = activities of daily living, KOOS = Knee injury and Osteoarthritis Outcome Score, LF = low frequency, HF = high frequency.

Table 3. Average survey measure scores for the KOOS subdomains.

Figure 3. a) Differences between treatment groups in the VR-12 MCS at baseline, 3 months, 6 months, and 9 months, with reported p-value for group by time interaction. (b) Differences between low frequency exercisers in treatment groups in MCS at baseline, 3 months, and 6 months. (c) Differences between high frequency exercisers in treatment groups in MCS at baseline, 3 months, and 6 months, with p-value for group by time interaction. (d) Differences between low frequency exercisers in treatment groups in MCS at baseline, 3 months, 6 months, and 9 months. (e) Differences between high frequency exercisers in treatment groups in MCS at baseline, 3 months, 6 months, and 9 months, with p-value for group by time interaction. AU = arbitrary units, g = grams, d = day, MCS = mental component score, LF = low frequency, HF = high frequency.

Figure 3. a) Differences between treatment groups in the VR-12 MCS at baseline, 3 months, 6 months, and 9 months, with reported p-value for group by time interaction. (b) Differences between low frequency exercisers in treatment groups in MCS at baseline, 3 months, and 6 months. (c) Differences between high frequency exercisers in treatment groups in MCS at baseline, 3 months, and 6 months, with p-value for group by time interaction. (d) Differences between low frequency exercisers in treatment groups in MCS at baseline, 3 months, 6 months, and 9 months. (e) Differences between high frequency exercisers in treatment groups in MCS at baseline, 3 months, 6 months, and 9 months, with p-value for group by time interaction. AU = arbitrary units, g = grams, d = day, MCS = mental component score, LF = low frequency, HF = high frequency.

Figure 4. (a) Differences between treatment groups in the VR-12 PCS at baseline, 3 months, 6 months, and 9 months, with reported p-value for group by time interaction. (b) Differences between males in treatment groups in the VR-12 PCS at baseline, 3 months, 6 months, and 9 months. (c) Differences between females in treatment groups in the VR-12 PCS at baseline, 3 months, 6 months, and 9 months. AU = arbitrary units, g = grams, d = day, PCS = physical component score.

Figure 4. (a) Differences between treatment groups in the VR-12 PCS at baseline, 3 months, 6 months, and 9 months, with reported p-value for group by time interaction. (b) Differences between males in treatment groups in the VR-12 PCS at baseline, 3 months, 6 months, and 9 months. (c) Differences between females in treatment groups in the VR-12 PCS at baseline, 3 months, 6 months, and 9 months. AU = arbitrary units, g = grams, d = day, PCS = physical component score.

Table 4. Average VR-12 mental and physical component scores.

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