Electrosprayed microparticles: a novel drug delivery method

Figures & data

Figure 1. Schematic illustration of various modes of electrospraying.

Figure 2. The effects of liquid properties on the electrospraying process.

Table 1. Drug loading and release characteristics of electrosprayed particles loaded with various bioactive agents.

Ref.	Needle and particle configuration	Polymer	Solvent	Active pharmaceutical agents and remarks	Size ($\mu \mathbf{m}$) range	Morphology	Cumulative release profiles
[3]*	Single needle	PLGA 50:50 (MW = 17,000Da) PLGA 75:25 (MW = 17,000Da)	Dimethylacetamide	Progesterone (insoluble) for hormone replacement therapy. Dissolution rate increased after encapsulation.	0.6–1.6
[5]*	Single needle	PLGA 50:50 (MW = 33,000Da)	Acetonitrile	Celecoxib (insoluble) molecularly dispersed in polymer matrix results in amorphous characteristics.	2.0–7.2
[6]*	Single needle	PLGA 50:50 (MW = 33,000Da)	Dimethylacetamide	Cisplatin (insoluble)	0.1–1.8
[7]*	Co-axial needle Single needle	PLGA 50:50 (MW = 33,000Da)	Dimethylacetamide	Cisplatin (insoluble)	0.3–1.2
[8]*	Co-axial needle	PVP	Ethanol Acetic acid Dimethylformamide	Paclitaxel, ultrasound triggered smart release	1.5–2.0
[9]*	Co-axial needle	Eudragit L-100	Ethanol Chloroform	Griseofulvin	0.8–2.7
[10]*	Co-axial needle	PLGA (MW = 10,000–20,000Da) PLGA (MW = 50,000–70,000Da)	Acetonitrile	Artemether	1.2–2.6
[12]*	Tri-axial needle	PLGA (MW = 20,000Da) PDLLA (MW = 75,000Da)	Acetonitrile 2,2,2-trifluoroethanol	Paclitaxel Doxorubicin	5.0–9.0
[11]*	Tri-axial needle	PCL (MW = 4,500Da)	Acetic acid	Magnetic Fe3O4 nanoparticles, for triggered release potential.	10.0–20.0

* [3], [6], [12] Reprinted with permission. Copyright (2019) Elsevier.

* [5] Reprinted with permission. Copyright (2019) Journal of the Royal Society Interface. Confirmation number: 11,806,308

* [7] Reprinted with permission. Copyright (2019) Dovepress.

* [8], [9], [10], [11] Reprinted with permission. Copyright (2019) American Chemical Society.

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