Local peroperative treatment with a bisphosphonate improves the fixation of total knee prostheses: A randomized, double-blind radiostereometric study of 50 patients

Figures & data

Box plot showing 10th, 25th, 50th, 75th, and 90th percentile and outliers for MTPM at 6, 12, and 24 months. Controls in blue, ibandronate-treated in red.

Results for maximal total point motion (MTPM) and sinking (trans y) in mm, and for forward tilting (rot x) and medial tilting (rot z) in degrees. Mean differences between control and ibandronate groups are given with 95% confidence interval (CI). P-values for Levene's test for equality of variances and for t-test are not corrected for multiplicity of comparisons and should be regarded as being descriptive

	Time (months)	Ibandronate		Control		Difference 95% CI			Levene p-value	t-test p-value
		mean	SD	mean	SD	mean	min.	max.
MTPM	6	0.32	0.11	0.44	0.18	0.13	0.04	0.21	0.01	0.005
MTPM	12	0.36	0.13	0.47	0.18	0.11	0.02	0.20	0.2	0.02
MTPM	24	0.40	0.12	0.47	0.17	0.07	–0.01	0.16	0.05	0.09
trans y	6	–0.06	0.10	0.02	0.11	0.08	0.02	0.14	0.3	0.01
trans y	12	–0.07	0.09	0.00	0.12	0.07	0.01	0.14	0.3	0.03
trans y	24	–0.06	0.10	0.02	0.11	0.08	0.02	0.15	0.8	0.009
rot x	6	–0.05	0.12	–0.06	0.17	–0.02	–0.10	0.07	0.04	0.7
rot x	12	–0.11	0.15	–0.10	0.24	0.01	–0.11	0.12	0.2	0.9
rot x	24	–0.09	0.16	–0.11	0.27	–0.02	–0.15	0.10	0.2	0.7
rot z	6	0.05	0.13	0.00	0.29	–0.06	–0.19	0.07	0.02	0.4
rot z	12	0.08	0.15	0.03	0.29	–0.06	–0.19	0.07	0.07	0.4
rot z	24	0.07	0.17	0.05	0.26	–0.02	–0.14	0.11	0.09	0.8