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Original papers

Platelet-rich plasma accelerated surgical angio-genesis in vascular-implanted necrotic bone: An experimental study in rabbits

, , , , &
Pages 106-110 | Received 28 Apr 2006, Accepted 10 Jan 2007, Published online: 08 Jul 2009

Figures & data

Figure 1. The experimental procedure. Blood was drawn off from each rabbit and anticoagulant was added. PRP was separated by a two-step centrifugation procedure. The necrotic bone was wrapped with a silicon sheet after injection of 1 ml of PRP into the hole, and it was then placed subcutaneously in the thigh.

Figure 1. The experimental procedure. Blood was drawn off from each rabbit and anticoagulant was added. PRP was separated by a two-step centrifugation procedure. The necrotic bone was wrapped with a silicon sheet after injection of 1 ml of PRP into the hole, and it was then placed subcutaneously in the thigh.

Figure 2. Microangiography 1 week after surgery; newly formed vessels could be seen along the implanted vascular bundle in the control group (left panel) and in the experimental group (right panel).

Figure 2. Microangiography 1 week after surgery; newly formed vessels could be seen along the implanted vascular bundle in the control group (left panel) and in the experimental group (right panel).

Figure 3. Microangiography 2 weeks after surgery; newly formed vessels could be seen along the implanted vascular bundle in the control group (left panel) and in the experimental group (right panel).

Figure 3. Microangiography 2 weeks after surgery; newly formed vessels could be seen along the implanted vascular bundle in the control group (left panel) and in the experimental group (right panel).

Figure 4. Mean angiographic score at 1 and 2 weeks after surgery. 1 week after surgery, that of the experimental group was 0.31 (SE 0.039), higher than that of the control group (0.18 (SE 0.039)) (p = 0.05). This difference was maintained at 2 weeks, when the mean angiographic score of the experimental group was 0.54 (SE 0.033) and that of the control group was 0.34 (SE 0.063) (p = 0.02).

Figure 4. Mean angiographic score at 1 and 2 weeks after surgery. 1 week after surgery, that of the experimental group was 0.31 (SE 0.039), higher than that of the control group (0.18 (SE 0.039)) (p = 0.05). This difference was maintained at 2 weeks, when the mean angiographic score of the experimental group was 0.54 (SE 0.033) and that of the control group was 0.34 (SE 0.063) (p = 0.02).

Figure 5. Mean length of newly formed vessels at 1 and 2 weeks after surgery. 1 week after surgery, the length of newly formed vessels in the experimental group (2.07 mm (SE 0.65)) was significantly greater than in the control group (0.98 (SE 0.32)) (p = 0.03). At 2 weeks, the mean vessel length in the experimental group was 3.3 (SE 0.16) and it was 2.3 (SE 0.3) in the control group (p = 0.01).

Figure 5. Mean length of newly formed vessels at 1 and 2 weeks after surgery. 1 week after surgery, the length of newly formed vessels in the experimental group (2.07 mm (SE 0.65)) was significantly greater than in the control group (0.98 (SE 0.32)) (p = 0.03). At 2 weeks, the mean vessel length in the experimental group was 3.3 (SE 0.16) and it was 2.3 (SE 0.3) in the control group (p = 0.01).

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