Figures & data
Table 1. DDRs signaling pathways involved in the Hallmarks of cancer. The “+” and the “-” represent DDRs promoting (+) or inhibiting (-) different biological functions depending on the cancer cell type. DDR1 is represented in green and DDR2 in red. (1) Malaguarnera et al., 2015, (2) Xiao et al., 2015, (3) Rudra-ganguly et al., 2014, (4) Assent et al., 2015,(5) Chetoui et al., 2011, (6) Hidalgo-Carcedo et al., 2011, (7) Juin et al., 2014, (8) Ezzoukhry et al., 2016,(9) Shimada et al., 2008, (10) Badiola et al., 2011a, (11) Saby et al., 2016, (12) Iwai et al., 2013, (13) Xie et al., 2015, (14) Wang et al., 2016,(15) Xu et al., 2014,(16) Pourdel et al., 2015, (17) Ren et al., 2014.
Figure 1. Different subcellular localization of DDRs in cells. Schematic representation that illustrates different subcellular localizations of DDRs in cells associated with their functions. 1) In A431 cells, DDR1 interacts with E cadherin and the polarity complex Par3/Par6 in order to maintain cell/cell junction. 2) In A375 cells, DDR1 and DDR2 colocalize together along the type I fibrillar collagen. 3) In A375 melanoma cells, on a collagen I matrix, DDR1 co-localizes with Tks5 (a marker of invadosomes). DDR1 activation induces Tuba/Cdc42 pathway leading to linear invadosome formation. 4) In A375 melanoma migrating cells, both DDR1 and DDR2 co-localize with lamellipodia. Some pathways induced by DDR1 activation are represented in this schematic. Scale bar: 5 µM The cells presented in this figure have been transfected by DDR1 tagged with GFP. Anti-DDR2 antibody was purchased from cell signaling (rabbit, 12133S), E-Cadherin antibody was purchased from abcam (mouse, 1416), anti-Tks5 was purchased from Santa Cruz biotechnology (rabbit, sc30122).
Figure 2. DDRs contribution in cancer hallmarks. Representative circular diagram of the hallmarks of cancer, adapted from Hanahan and Weinberg, 2011. In the center, a representative confocal image of a melanoma cancer cell (A375) seeded into collagen fibers (grey) and expressing DDR1 (red). The nucleus is in blue. The difference in the front size is related to the reported involvement of one of hte DDR more than the other in the literature.
