Figures & data
Figure 1. Evolution of knowledge and tools in immunology. Cr release assay = chromium release assay, MHC = major histocompatibility complex, Treg = T-regulatory cells, TLR = toll-like receptors, NLR = NOD-like receptors.
Figure 2. Adjuvant Systems: key developmental milestones. POC = proof of concept.
Table 1. GSK's Adjuvant Systems.
Table 2. Impact of composition on the physical properties of oil-in-water emulsions (a subset of more than 60 tested formulations). Key requirements were stability over time after freeze/thaw, and sterile filterability (<200 nm). Shaded area represents the selected emulsion known as AS03.
Figure 3. Lytic action of QS-21 is abrogated in cholesterol-based liposomes.
Figure 4. General mode of action of an adjuvant (adapted fromCitation104).
