Figures & data
Figure 1. YF-LAV annual requirements to eliminate Yellow Fever. The World Health Organization suggests that a total of 138.4 million vaccine doses are required to eliminate Yellow Fever from Africa, Central, South America, and the Caribbean. However, the annual vaccine needs are significantly higher than the total production of all six manufacturers running at full capacity. Currently, an unmet requirement of 58.4 million doses remains per annum. In this graphic depiction of the annual vaccine needs each ‘syringe’ represents 1.3 million vaccine doses.
Figure 2. Overlapping distribution of Yellow Fever virus and Aedes aegypti’s probability of occurrence. According to the World Health Organization 47 countries in Africa, and Central and South America are considered Yellow Fever endemic countries (Yellow). YF endemic areas are regions where Yellow Fever virus circulation has been reported in either sylvatic or urban cycles, and therefore hold a potential risk of Yellow Fever virus transmission. Transmission of YF in non-endemic areas can be perpetuated upon importation of a YF infected subject to a region endemic to Yellow Fever’s main vector, the Aedes aegypti mosquito. Extensive widespread of Aedes mosquitoes (Orange) and the upsurge in international human migration puts half of the world’s population at risk upon YF importation.
Table 1. General features of novel vaccine candidates against Yellow fever