https://orcid.org/0000-0001-5067-5602
Figures & data
Table 1 Characteristics of the dataset.
Table 2 Correlation of muscle strength measurements with ALSFRS-R domains.
Table 3 Correlation of muscle strength with ALSAQ-5 items.
Table 4 Correlation of SVC with ALSFRS-R respiratory scores.
Figure 1 Predicted ALSFRS-R domain sub-scores versus categories of (A) hand grip strength, (B) upper-extremity muscle strength, and (C) lower-extremity muscle strength.
Diamonds indicate the mean. Box edges indicate the 25th to 75th percentiles (the interquartile range), horizontal lines in between the edges indicate the medians, whiskers extend to the upper and lower adjacent values, and circles represent outlier values. The adjacent values are the lowest and highest observations that are still inside the region, defined by the following limits: lower limit, Q1 minus 1.5 x (Q3 minus Q1); upper limit, Q3 plus 1.5 x (Q3 minus Q1).
The maximum score is 12 for either the fine motor or gross motor domain. Upper-extremity muscles include wrist extension, first dorsal interosseous, and elbow flexion strength. Lower-extremity muscles include ankle dorsiflexion, hip flexor, and knee extension strength.
ALSFRS-R: ALS Functional Rating Scale–Revised.
Data availability statement
Data reported herein are part of a sponsor-led clinical development programme that is ongoing, and thus complete datasets for the trial will not be made available with this report.