Evaluation and study of antimicrobial activity of nanoliposomal meropenem against Pseudomonas aeruginosa isolates

Figures & data

Figure 1. Size (a), zeta potential (b), and scanning electron microscopy image (c) of meropenem-loaded liposome.

Table 1. Antimicrobial activities of free and liposomal meropenem on clinical and laboratory strains of P. aeruginosa Strains.

Strains		Liposomal meropenem			Free meropenem			Carbapenemase production
Clinical Strains		MIC	MBC	MBEC	MIC	MBC	MBEC	–
	T-11	1.5	6.25	1.5	125	250	50	–
	T-145	6.25	25	1.5	62.5	125	6.25	–
	T-2	6.25	25	1.5	62.5	125	6.25	+
	T-3	50	100	1.5	125	250	50	–
	O-68	100	250	1.5	250	NA	100	–
	O-135	6.25	50	1.5	25	250	6.25	–
	O-46	100	250	1.5	250	NA	100	–
Laboratory strains	GIM-1	6.25	25	1.5	62.5	125	6.25	+
	IPM-2	50	100	1.5	250	NA	6.25	+

NA: not assay.

Figure 2. Effect of sub-inhibitory concentrations of free and liposomal meropenem on P. aeruginosa motility.