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Research Article

Novel methotrexate soft nanocarrier/fractional erbium YAG laser combination for clinical treatment of plaque psoriasis

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Pages 996-1002 | Received 30 Jan 2018, Accepted 09 Feb 2018, Published online: 15 Feb 2018

Figures & data

Table 1. Clinical data of the patients.

Figure 1. Assessment of the left elbow psoriatic lesion treated with MTX microemulsion formulation only along the treatment course for patient 1: (A) before treatment, (B) after 3 weeks of treatment and (C) after 8 weeks of treatment.

Figure 1. Assessment of the left elbow psoriatic lesion treated with MTX microemulsion formulation only along the treatment course for patient 1: (A) before treatment, (B) after 3 weeks of treatment and (C) after 8 weeks of treatment.

Figure 2. Assessment of the right elbow psoriatic lesion treated with MTX microemulsion formulation/fractional erbium:YAG laser along the treatment course for patient 1: (A) before treatment, (B) after 3 weeks of treatment and (C) after 8 weeks of treatment.

Figure 2. Assessment of the right elbow psoriatic lesion treated with MTX microemulsion formulation/fractional erbium:YAG laser along the treatment course for patient 1: (A) before treatment, (B) after 3 weeks of treatment and (C) after 8 weeks of treatment.

Figure 3. Assessment of the left knee psoriatic lesion treated with MTX microemulsion formulation only along the treatment course for patient 2: (A) before treatment, (B) after 3 weeks of treatment and (C) after 8 weeks of treatment.

Figure 3. Assessment of the left knee psoriatic lesion treated with MTX microemulsion formulation only along the treatment course for patient 2: (A) before treatment, (B) after 3 weeks of treatment and (C) after 8 weeks of treatment.

Figure 4. Assessment of the right knee psoriatic lesion treated with MTX microemulsion formulation/fractional erbium:YAG laser along the treatment course for patient 2: (A) before treatment, (B) after 3 weeks of treatment and (C) after 8 weeks of treatment.

Figure 4. Assessment of the right knee psoriatic lesion treated with MTX microemulsion formulation/fractional erbium:YAG laser along the treatment course for patient 2: (A) before treatment, (B) after 3 weeks of treatment and (C) after 8 weeks of treatment.

Table 2. TES score of psoriatic plaques before and after 3 and 8 weeks of the treatment.

Figure 5. Patient with psoriatic plaques over the right elbow before treatment with microemulsion/laser combination (A,C) and after 8 weeks of treatment (B,D), showing a decreased epidermal thickness.

Figure 5. Patient with psoriatic plaques over the right elbow before treatment with microemulsion/laser combination (A,C) and after 8 weeks of treatment (B,D), showing a decreased epidermal thickness.

Table 3. Comparison between right and left psoriatic plaques regarding the percent change of TES score after 3 and 8 weeks of treatment course.

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