Combined vaccines for prophylaxis of infectious conditions

Figures & data

Figure 1. Contraindications for MMRV vaccine.

Figure 2. Types of carrier proteins used in vaccines.

Table 1. Marketed preparations of polysaccharide vaccines for typhoid.

Vaccine type	Manufacture	Product name
Purified Vi polysaccharide parenteral vaccine	A. Sanofi Pasteur vaccines	Typhim Vi
	B. GSK Biologics	Typherix
Ty2la live oral vaccine	A. Crucell	Vivotif Berna
	B. Boryung Pharmaceutical Co. Ltd	Zerotyph
Purified Vi polysaccharide-tetanus toxoid conjugate parenteral vaccine	A. Bio-med private limited	Peda typh

Table 2. Types of polysaccharide vaccine for pneumonia.

PPSV23	PCV7	PCV13
Pneumococcal capsular polysaccharide Contains antigens from 23 types of pneumonia	Contains 7 serotypes	Purified capsular polysaccharide of 13 serotypes of S. pneumoniae.
The vaccine contains the following capsular serotypes: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F and 33F	Contains 4, 6B, 9V, 14, 18C, 19F and 23F	Contains 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F
Given as single-dose of 0.5 mL or a multidose 5.0-mL vial to be administered either intramuscularly or subcutaneously into the deltoid muscle or lateral mid-thigh.		Given as a prefilled single-dose 0.5-mL syringe for intramuscular injection in the anterolateral aspect of the thigh in infants and in the deltoid muscle of the upper arm in infants, children and adults.

Figure 3. Advantages of mRNA vaccine.

Figure 4. Structures of mRNA from alphavirus.

Figure 5. Self-amplifying mRNA targeting mammalian cell.